{"doi":"10.1016/j.envint.2024.109058","title":"Serum concentrations of per- and polyfluorinated substances and risk of B-cell non-Hodgkin lymphoma","abstract":"Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants that are detectable in the serum of most U.S. adults. Some studies of highly-exposed individuals have suggested positive associations between PFAS and B-cell non-Hodgkin lymphoma (B-NHL). To investigate whether associations exist at lower exposure levels, we conducted a nested case-control study investigating serum PFAS concentrations and B-NHL within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. We measured pre-diagnostic serum concentrations of five PFAS among 706 cases (age at diagnosis = 55–93 years, median 73 years) and 706 controls individually matched on age at blood draw, sex, self-reported race and ethnicity, study center, and year of blood collection (the median follow-up years = 10). We estimated odds ratios (ORs) and 95 % confidence intervals (CIs) for PFAS concentrations in relation to B-NHL, both overall and for selected histologic subtypes [diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), and marginal zone lymphoma (MZL)] using conditional logistic regression. We found no evidence of a positive association with B-NHL for any of the five PFAS. In analyses of histologic subtypes, perfluorohexane sulfonate (PFHxS) was significantly associated with DLBCL in a model adjusting for all other PFAS (OR for highest vs. lowest quintile = 2.19, 95 % CI = 1.21, 3.95; P trend = 0.02), but not in a model without mutual adjustment (OR = 1.37, 95 % CI = 0.82, 2.29; P trend = 0.26). We also observed an inverse association between perfluorononanoate and DLBCL (mutually-adjusted OR = 0.83, 95 % CI = 0.69, 0.99 per doubling in concentration), although the association was null among participants with blood drawn prior to 1997 (OR <1997 = 1.00, 95 % CI = 0.82, 1.21; OR ≥1997 = 0.65, 95 % CI = 0.53, 0.79; P interaction = 0.0003). In conclusion, our findings from a prospective cohort study with PFAS serum concentrations comparable to that of the general population do not support an association with increased risk of B-NHL overall. The suggestive evidence of a positive association between PFHxS and DLBCL warrants further investigation.","journal":"Environment International","year":2024,"id":466501,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9557,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1047223,"name":"Jani Koponen","orcid":"0000-0003-3361-6787","position":1,"is_corresponding":false},{"id":241829,"name":"Joshua N. Sampson","orcid":"0000-0003-2875-3365","position":2,"is_corresponding":false},{"id":105707,"name":"Alexander P. Keil","orcid":"0000-0002-0955-6107","position":3,"is_corresponding":false},{"id":282614,"name":"Mary H. Ward","orcid":"0000-0001-7584-8856","position":4,"is_corresponding":false},{"id":241832,"name":"Jonathan N. Hofmann","orcid":"0000-0002-1043-5812","position":5,"is_corresponding":false},{"id":241825,"name":"Wen‐Yi Huang","orcid":"0000-0002-4440-3368","position":6,"is_corresponding":false},{"id":241830,"name":"Debra T. Silverman","orcid":"0000-0001-8894-0301","position":7,"is_corresponding":false},{"id":1047222,"name":"Panu Rantakokko","orcid":"0000-0002-8624-1387","position":8,"is_corresponding":false},{"id":241831,"name":"Mark P. Purdue","orcid":"0000-0003-1177-3108","position":9,"is_corresponding":false},{"id":733787,"name":"Jongeun Rhee","orcid":"0000-0003-1873-9359","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-19T02:05:06.743102Z","pmid":"39388845","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}