{"doi":"10.1016/j.envint.2024.108575","title":"Translational toxicoepigenetic Meta-Analyses identify homologous gene DNA methylation reprogramming following developmental phthalate and lead exposure in mouse and human offspring","abstract":"Although toxicology uses animal models to represent real-world human health scenarios, a critical translational gap between laboratory-based studies and epidemiology remains. In this study, we aimed to understand the toxicoepigenetic effects on DNA methylation after developmental exposure to two common toxicants, the phthalate di(2-ethylhexyl) phthalate (DEHP) and the metal lead (Pb), using a translational paradigm that selected candidate genes from a mouse study and assessed them in four human birth cohorts. Data from mouse offspring developmentally exposed to DEHP, Pb, or control were used to identify genes with sex-specific sites with differential DNA methylation at postnatal day 21. Associations of human infant DNA methylation in homologous mouse genes with prenatal DEHP or Pb were examined with a meta-analysis. Differential methylation was observed on 6 cytosines (adjusted-p < 0.05) and 90 regions (adjusted-p < 0.001). This translational approach offers a unique method that can detect conserved epigenetic differences that are developmentally susceptible to environmental toxicants.","journal":"Environment International","year":2024,"id":453431,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9454,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":325572,"name":"Dana C. Dolinoy","orcid":"0000-0002-3304-2456","position":1,"is_corresponding":false},{"id":996580,"name":"Kai Wang","orcid":"0000-0002-8541-7563","position":2,"is_corresponding":false},{"id":1011506,"name":"Luke Montrose","orcid":"0000-0002-9829-3029","position":3,"is_corresponding":false},{"id":232456,"name":"Vasantha Padmanabhan","orcid":"0000-0002-8443-7212","position":4,"is_corresponding":false},{"id":337962,"name":"Karen E. Peterson","orcid":"0000-0003-0471-1427","position":5,"is_corresponding":false},{"id":245914,"name":"Douglas M. Ruden","orcid":"0000-0002-0070-437X","position":6,"is_corresponding":false},{"id":363234,"name":"Maureen A. Sartor","orcid":"0000-0001-6155-5702","position":7,"is_corresponding":false},{"id":735023,"name":"Laurie K. Svoboda","orcid":"0000-0002-0003-4513","position":8,"is_corresponding":false},{"id":307119,"name":"Martha María Téllez‐Rojo","orcid":"0000-0003-3322-3334","position":9,"is_corresponding":false},{"id":325569,"name":"Jaclyn M. Goodrich","orcid":"0000-0002-8289-9253","position":10,"is_corresponding":false},{"id":380329,"name":"Rebekah Petroff","orcid":"0000-0002-5539-7688","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":null,"created_at":"2026-07-19T02:02:58.784290Z","pmid":"38507935","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}