{"doi":"10.1016/j.envint.2022.107078","title":"Prenatal phthalate exposure in relation to placental corticotropin releasing hormone (pCRH) in the CANDLE cohort","abstract":"CONTEXT: Phthalates may disrupt maternal-fetal-placental endocrine pathways, affecting pregnancy outcomes and child development. Placental corticotropin releasing hormone (pCRH) is critical for healthy pregnancy and child development, but understudied as a target of endocrine disruption. OBJECTIVE: To examine phthalate metabolite concentrations (as mixtures and individually) in relation to pCRH. DESIGN: Secondary data analysis from a prospective cohort study. SETTING: Prenatal clinics in Tennessee, USA. PATIENTS: 1018 pregnant women (61.4% non-Hispanic Black, 32% non-Hispanic White, 6.6% other) participated in the CANDLE study and provided data. Inclusion criteria included: low-medical-risk singleton pregnancy, age 16-40, and gestational weeks 16-29. INTERVENTION: None. MAIN OUTCOME MEASURES: Plasma pCRH at two visits (mean gestational ages 23.0 and 31.8 weeks) and change in pCRH between visits (ΔpCRH). RESULTS: In weighted quantile sums (WQS) regression models, phthalate mixtures were associated with higher pCRH at Visit 1 (β = 0.07, 95 %CI: 0.02, 0.11) but lower pCRH at Visit 2 (β = -0.08, 95 %CI: -0.14, -0.02). In stratified analyses, among women with gestational diabetes (n = 59), phthalate mixtures were associated with lower pCRH at Visit 1 (β = -0.17, 95 %CI: -0.35, 0.0006) and Visit 2 (β = -0.35, 95 %CI: -0.50, -0.19), as well as greater ΔpCRH (β = 0.16, 95 %CI: 0.07, 0.25). Among women with gestational hypertension (n = 102), phthalate mixtures were associated with higher pCRH at Visit 1 (β = 0.20, 95 %CI: 0.03, 0.36) and Visit 2 (β = 0.42; 95 %CI: 0.19, 0.64) and lower ΔpCRH (β = -0.17, 95 %CI: -0.29, -0.06). Significant interactions between individual phthalate metabolites and pregnancy complications were observed. CONCLUSIONS: Phthalates may impact placental CRH secretion, with differing effects across pregnancy. Differences in results between women with and without gestational diabetes and gestational hypertension suggest a need for further research examining whether women with pregnancy complications may be more vulnerable to endocrine-disrupting effects of phthalates.","journal":"Environment International","year":2022,"id":268735,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9622,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":930933,"name":"Matthew Corsetti","orcid":"0000-0001-5072-518X","position":1,"is_corresponding":false},{"id":658118,"name":"Drew B. Day","orcid":"0000-0003-2606-2050","position":2,"is_corresponding":false},{"id":361059,"name":"Sally W. Thurston","orcid":"0000-0003-2538-762X","position":3,"is_corresponding":false},{"id":325490,"name":"Christine T. Loftus","orcid":"0000-0002-5232-7342","position":4,"is_corresponding":false},{"id":325491,"name":"Catherine J. Karr","orcid":"0000-0002-4683-2270","position":5,"is_corresponding":false},{"id":291977,"name":"Kurunthachalam Kannan","orcid":"0000-0002-1926-7456","position":6,"is_corresponding":false},{"id":275838,"name":"Kaja Z. LeWinn","orcid":"0000-0002-8245-7279","position":7,"is_corresponding":false},{"id":264426,"name":"Alicia K. Smith","orcid":"0000-0002-8537-5156","position":8,"is_corresponding":false},{"id":465084,"name":"Roger Smith","orcid":"0000-0003-4720-0280","position":9,"is_corresponding":false},{"id":325492,"name":"Frances A. Tylavsky","orcid":"0000-0002-9479-8003","position":10,"is_corresponding":false},{"id":275836,"name":"Nicole R. Bush","orcid":"0000-0003-0217-9975","position":11,"is_corresponding":false},{"id":325493,"name":"Sheela Sathyanarayana","orcid":"0000-0002-1480-0397","position":12,"is_corresponding":false},{"id":228378,"name":"Emily S. Barrett","orcid":"0000-0001-9463-524X","position":0,"is_corresponding":true}],"reference_count":102,"raw_metadata":null,"created_at":"2026-07-19T00:27:14.088663Z","pmid":"35007898","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}