{"doi":"10.1016/j.envint.2020.105935","title":"Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes","abstract":"In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation of perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pregnancy, on lipid and immune-related markers of T1D risk in children. In a mother-infant cohort (264 dyads), high PFAS exposure during pregnancy associated with decreased cord serum phospholipids and progression to T1D-associated islet autoantibodies in the offspring. This PFAS-lipid association appears exacerbated by increased human leukocyte antigen-conferred risk of T1D in infants. Exposure to a single PFAS compound or a mixture of organic pollutants in non-obese diabetic mice resulted in a lipid profile characterized by a similar decrease in phospholipids, a marked increase of lithocholic acid, and accelerated insulitis. Our findings suggest that PFAS exposure during pregnancy contributes to risk and pathogenesis of T1D in offspring.","journal":"Environment International","year":2020,"id":65090,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":63,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.959,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":344333,"name":"Tim Sinioja","orcid":"0000-0002-8424-8833","position":1,"is_corresponding":false},{"id":344334,"name":"Santosh Lamichhane","orcid":"0000-0002-9292-3595","position":2,"is_corresponding":false},{"id":344335,"name":"Partho Sen","orcid":"0000-0003-0475-2763","position":3,"is_corresponding":false},{"id":344336,"name":"Johanna Bodin","orcid":"0000-0001-6556-3486","position":4,"is_corresponding":false},{"id":344337,"name":"Heli Siljander","orcid":"0000-0002-6899-2822","position":5,"is_corresponding":false},{"id":344338,"name":"Alex M. Dickens","orcid":"0000-0002-3178-8449","position":6,"is_corresponding":false},{"id":344339,"name":"Dawei Geng","orcid":"0000-0002-8553-8824","position":7,"is_corresponding":false},{"id":346282,"name":"Cecilia Carlsson","orcid":null,"position":8,"is_corresponding":false},{"id":346283,"name":"Daniel Duberg","orcid":null,"position":9,"is_corresponding":false},{"id":344340,"name":"Jorma Ilonen","orcid":"0000-0002-9973-2062","position":10,"is_corresponding":false},{"id":344341,"name":"Suvi Μ. Virtanen","orcid":"0000-0001-8928-0878","position":11,"is_corresponding":false},{"id":344342,"name":"Hubert Dirven","orcid":"0000-0002-7686-9947","position":12,"is_corresponding":false},{"id":346284,"name":"Hanne Friis Berntsen","orcid":null,"position":13,"is_corresponding":false},{"id":346285,"name":"Karin Zimmer","orcid":null,"position":14,"is_corresponding":false},{"id":344343,"name":"Unni C. Nygaard","orcid":"0000-0002-2955-9970","position":15,"is_corresponding":false},{"id":41071,"name":"Matej Orešič","orcid":"0000-0002-2856-9165","position":16,"is_corresponding":false},{"id":344344,"name":"Mikael Knip","orcid":"0000-0003-0474-0033","position":17,"is_corresponding":false},{"id":54288,"name":"Tuulia Hyötyläinen","orcid":"0000-0002-1389-8302","position":18,"is_corresponding":false},{"id":344332,"name":"Aidan McGlinchey","orcid":"0000-0001-6682-6030","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-18T21:13:23.327603Z","pmid":"32634666","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}