{"doi":"10.1016/j.envadv.2025.100623","title":"Elevated per- and polyfluoroalkyl substances (PFASs) in tap water and serum in a community near an abandoned paper mill","abstract":"In 2018, elevated concentrations of per- and polyfluoroalkyl substances (PFASs) (1600 ng/L) were discovered in municipal wells, and the groundwater contamination was linked to an abandoned paper mill landfill in southwestern Michigan. From 2020-2021, we conducted a detailed exposure assessment in this community to provide insights about the mixture of PFASs from a paper mill source in drinking water and their persistence in human serum following long-term exposure. Water and serum were analyzed for >30 PFASs using LC-MS/MS. Approximately half of the study participants had private wells with lower PFAS concentrations (<220 ng/L) compared to municipal water (1600 ng/L), therefore, they were assigned as low (private well) and high (municipal well) exposure groups. The three predominant PFASs detected in the municipal well, perfluorooctanoic acid (PFOA) (670 ng/L), perfluorooctane sulfonic acid (PFOS) (740 ng/L), and perfluorohexane sulfonic acid (PFHxS) (19 ng/L), were also the most abundant in serum. Participants with high drinking water exposure had serum PFOA, PFOS and PFHxS concentrations that were 15-fold, 5-fold, and 2-fold higher, respectively, compared to those in the low group. For each additional year participants reported drinking the municipal water, we observed a 6 %, 4 %, and 5 % increase in serum PFOA, PFOS and PFHxS, respectively. Overall, these results highlight the role of drinking water as a predominant source of PFAS exposure and the risk that abandoned landfills can pose to drinking water in nearby communities. This study also establishes a baseline for long-term toxicological impacts and evaluation of intervention effectiveness.","journal":"Environmental Advances","year":2025,"id":532048,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9227,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1412814,"name":"Ankita Bhattacharya","orcid":"0009-0001-9641-4501","position":1,"is_corresponding":false},{"id":1412815,"name":"Y. Q. Guo","orcid":"0009-0003-6525-954X","position":2,"is_corresponding":false},{"id":844464,"name":"Sharon Zhang","orcid":"0000-0002-6250-9879","position":3,"is_corresponding":false},{"id":406236,"name":"Heather M. Stapleton","orcid":"0000-0002-9995-6517","position":4,"is_corresponding":false},{"id":294113,"name":"John L. Adgate","orcid":"0000-0003-1271-3465","position":5,"is_corresponding":false},{"id":1412816,"name":"Sarah Choyke","orcid":"0000-0003-3170-5452","position":6,"is_corresponding":false},{"id":790996,"name":"Christopher P. Higgins","orcid":"0000-0001-6220-8673","position":7,"is_corresponding":false},{"id":289458,"name":"Courtney C. Carignan","orcid":"0000-0002-5500-0222","position":8,"is_corresponding":false},{"id":1042099,"name":"Rachel A. Bauer","orcid":null,"position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T02:51:18.928280Z","pmid":"42338495","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}