{"doi":"10.1016/j.eng.2021.06.020","title":"Engineered Vasculature for Organ-on-a-Chip Systems","abstract":null,"journal":"Engineering","year":2022,"id":654448,"datarank":0.6238324625039509,"base_score":4.1588830833596715,"endowment":4.1588830833596715,"self_citation_contribution":0.6238324625039509,"citation_network_contribution":0.0,"self_endowment_contribution":0.6238324625039509,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":63,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":346109,"name":"Hongzhao Zhou","orcid":null,"position":1,"is_corresponding":false},{"id":1091639,"name":"Yuting Li","orcid":"0009-0005-3442-5941","position":2,"is_corresponding":false},{"id":241268,"name":"Mengfei Yu","orcid":"0000-0002-7700-4697","position":3,"is_corresponding":false},{"id":958744,"name":"Xiaobin Xu","orcid":"0000-0001-7832-2825","position":4,"is_corresponding":false},{"id":1392739,"name":"Yutong Wu","orcid":"0000-0003-1215-8932","position":5,"is_corresponding":false},{"id":970454,"name":"Liang Ma","orcid":"0000-0002-6102-5821","position":6,"is_corresponding":false},{"id":478840,"name":"Bin Zhang","orcid":"0000-0001-8835-8370","position":7,"is_corresponding":false},{"id":1629800,"name":"Huayong Yang","orcid":null,"position":8,"is_corresponding":false},{"id":1629797,"name":"Abdellah Aazmi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Engineered Vasculature for Organ-on-a-Chip Systems","abstract":"Organ-on-a-chip technology, a promising three-dimensional (3D) dynamic culture method, ensures accurate and efficient cell culture and has great potential for replacing animal models in preclinical testing. The circulatory system, the most abundant organ in the human body, plays a crucial role in oxygen exchange and mass transfer, which is the determining factor for the survival of tissues and organs. Thus, it is essential to integrate the circulatory system into an organ-on-a-chip to recreate tissue and organ microenvironments and physiological functions. This review discusses the synergy between the vasculature and the emerging organ-on-a-chip technology, which offers even better possibilities of duplicating physiology and disease characteristics. In addition, we review the different steps of a vascularized organ-on-a-chip fabrication process, including structure fabrication and tissue construction using different biofabrication strategies. Finally, we outline the applicability of this technology in the fascinating and fast-developing field of organ and tumor culture.","is_dataset_classified":null,"base_score":4.1588830833596715,"endowment":4.1588830833596715,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19162232","pmcid":null,"openalex_id":"https://openalex.org/W3195547770","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"51875518","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"2018YFA0703000","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"2019XZZX003-02","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"2020QNA4001","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"2017C01054","title":null}],"total_grants":5,"fwci":3.3396,"citation_percentile":0.93313348,"influential_citations":0,"citation_trend":[{"year":2022,"count":7},{"year":2023,"count":13},{"year":2024,"count":26},{"year":2025,"count":11},{"year":2026,"count":6}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S2095809921003337/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S2095809921003337/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2095809921003337?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2095809921003337?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.eng.2021.06.020","host_type":"journal"},{"url":"https://doaj.org/article/2bc42e178b034a0aa2036bbca4893870","host_type":"repository"}],"fields_of_study":["3D Printing in Biomedical Research","Cancer Cells and Metastasis","Innovative Microfluidic and Catalytic Techniques Innovation"],"mesh_terms":[],"keywords":["Biofabrication","Organ-on-a-chip","Organ culture","Organ system","Process (computing)","Computer science","Tissue engineering","Biology","Pathology","Medicine","Nanotechnology","Biomedical engineering","Disease","Materials science"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Industry, innovation and infrastructure"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T06:43:20.569538Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}