{"doi":"10.1016/j.eng.2020.08.012","title":"Challenges in the Development of a Vaccine Against COVID-19","abstract":null,"journal":"Engineering","year":2020,"id":645258,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1528744,"name":"Feng-Cai Zhu","orcid":null,"position":1,"is_corresponding":false},{"id":395664,"name":"Wei Chen","orcid":"0000-0001-5451-6430","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Challenges in the Development of a Vaccine Against COVID-19","abstract":"Abstract   SARS-CoV-2, the causal agent of COVID-19, has become a major public health issue. The severe morbidity and mortality associated with SARS-CoV-2 necessitate the development of effective vaccines to prevent epidemics. There is an unprecedented need to produce and distribute enough safe and effective vaccines to individuals globally. Here, we discuss the challenges in several aspects including the vaccine safety, vaccine efficacy, human challenge trials and production capacity in COVID-19 vaccine development.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32953196","pmcid":"PMC7489243","openalex_id":"https://openalex.org/W3084503292","authors":[],"funders":[],"total_grants":0,"fwci":0.0487,"citation_percentile":0.45020183,"influential_citations":0,"citation_trend":[{"year":2021,"count":2},{"year":2024,"count":1}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.eng.2020.08.012","host_type":"journal"},{"url":"https://doi.org/10.1016/j.eng.2020.08.012","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2095809920302459?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2095809920302459?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32953196","host_type":"repository"},{"url":"https://doaj.org/article/472aa083732c445eaf7108c0de79e891","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7489243","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC7489243","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC7489243?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["SARS-CoV-2 and COVID-19 Research","Vaccine Coverage and Hesitancy","COVID-19 Clinical Research Studies"],"mesh_terms":[],"keywords":["Coronavirus disease 2019 (COVID-19)","Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","2019-20 coronavirus outbreak","Medicine","Public health","Virology","Business","Intensive care medicine","Environmental health","Risk analysis (engineering)","Outbreak","Disease","Infectious disease (medical specialty)"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T04:06:09.276272Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}