{"doi":"10.1016/j.ekir.2025.03.052","title":"Spectrum of Kidney Pathology in Patients With Syphilis","abstract":"Introduction: Syphilis has been associated with multiple kidney diseases, primarily studied within small series. A large cohort of patients with active syphilis who underwent kidney biopsy were examined to evaluate the histopathologic spectrum and clinicopathologic features of the disease. Methods: Patients with syphilis who underwent a native kidney biopsy were identified from renal pathology archives at Arkana Laboratories. Patients were identified through a clinical history of active syphilis in medical records and/or positive serologic testing (rapid plasma reagin, venereal disease research laboratory, or antitreponemal antibodies). Results: = 7). Of the patients with MN (28.4%), the majority were neuron-derived neurotropic factor (NDNF) positive and frequently demonstrated staining for multiple immune reactants, particularly C1q. Of the patients with HIV-associated pathology (20.6%), 81.0% had collapsing glomerulopathy and 33.3% had mesangial immune complex deposition (HIV-associated immune complex disease of the kidney [HIVICK]). Most patients with AIN (70%) demonstrated plasma cell-rich interstitial infiltrates. Conclusion: A spectrum of kidney pathology diagnoses is seen in patients with syphilis, with the majority of patients presenting with AKI. Coinfections, and pathology related to coinfections, were common.","journal":"Kidney International Reports","year":2025,"id":518170,"datarank":0.32599392640827535,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.014077695156299898,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.014077695156299898,"corpus_percentile":47.45107140094376,"corpus_rank":6794,"citation_count":7,"citer_count":7,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.6048,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":4.1667,"fair_percentile":4.891470498318557,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":245937,"name":"Aaron J. Storey","orcid":"0000-0003-4089-5008","position":1,"is_corresponding":false},{"id":248439,"name":"Samar Hassen","orcid":null,"position":2,"is_corresponding":false},{"id":245941,"name":"Christopher P. Larsen","orcid":"0000-0002-7175-0242","position":3,"is_corresponding":false},{"id":245935,"name":"Tiffany Caza","orcid":"0000-0001-8988-8998","position":4,"is_corresponding":false},{"id":1385134,"name":"Diana Fang","orcid":"0000-0001-7644-0377","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":null,"created_at":"2026-07-19T02:49:04.756302Z","pmid":"40630295","pmcid":"PMC12231011","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":0.0,"fair_a":0.0,"fair_i":0.0,"fair_r":33.3333,"fair_zscore":-1.1986,"fair_rationale":{"fair_score":4.17,"has_llm":true,"taxonomy_version":"fair_taxonomy_v5","dimensions":{"F":{"name":"Findable","score":0.0,"criteria":[{"key":"f_dataset_pid","label":"Persistent identifier for the data","kind":"llm","weight":2.0,"fraction":0.0,"verdict":"no","evidence":"Essentially all data is included in this manuscript. 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[majority verdict 'no' (3/5 passes agreed)]","gain":0.0,"priority":"useful","scored":false}],"suggestions":["Mint or cite a persistent identifier for the dataset — a repository DOI or an accession from a registered repository — and print it in the paper. A bare URL is not persistent: it is the single most common cause of a dead data link five years after publication. For clinical / human-subjects data, deposit in dbGaP or the European Genome-phenome Archive (EGA).","Deposit the data in a repository registered in re3data/FAIRsharing (a domain repository such as GEO, SRA, dbGaP, PRIDE, or a generalist such as Zenodo, Dryad, Dataverse) and name it explicitly in the paper. A lab website is not an archive: it has no retention commitment and no accession. For clinical / human-subjects data, deposit in dbGaP or the European Genome-phenome Archive (EGA).","Remove the precondition or justify it. Release the data at publication with no embargo, no registration wall, and no approval step — NIH's zero-embargo public- access rule (NOT-OD-25-101) has already made 'available at publication' the federal baseline for the article; the data should not lag behind it. For clinical / human-subjects data, deposit in dbGaP or the European Genome-phenome Archive (EGA).","Attach a standard, machine-readable open licence to the deposit — CC0 or CC BY, which is what Horizon Europe and most funders expect — and print the licence identifier in the paper. 'Free to use' is not a licence: it grants nothing a reuser's institution can rely on.","Cite the dataset in the reference list like a publication — creator, year, title, repository, DOI/accession — and cite it in-text where it is used. Only a reference- list entry is machine-readable to Crossref/DataCite, and only a citation lets the data earn credit. Cite the clinical / human-subjects repository accession (e.g. from dbGaP or the European Genome-phenome Archive (EGA)) in the reference list."],"model":"deepseek/deepseek-v4-flash","agent_version":"fair_agent_v8","fulltext_source":"epmc_xml"},"fair_model":"deepseek/deepseek-v4-flash","fair_agent_version":"fair_agent_v8","fair_fulltext_source":"epmc_xml","fair_has_llm":true,"fair_computed_at":"2026-07-20T12:43:10.573420Z","clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}