{"doi":"10.1016/j.ekir.2024.05.025","title":"Prospective Study on Kidney Dysfunction Markers and Risk for Mortality among South Asians","abstract":"BackgroundAssociations between markers of impaired kidney function and adverse outcomes among South Asians is understudied and could differ from existing data derived mostly from North American or European cohorts.MethodsWe conducted a prospective analysis of 9,797 participants from the ongoing cArdiometabolic Risk Reduction study in South Asia, India. We examined the associations between baseline spot urine albumin-to-creatinine (UACR) ratio and creatinine-based glomerular filtration rate (eGFR) estimating equations with all-cause mortality using Cox proportional hazards regression, adjusting for baseline age, sex, diabetes, systolic blood pressure, tobacco, history of cardiovascular disease, and cholesterol. Additionally, we calculated population attributable fraction (PAF) for both markers.ResultsOver a median 7-year follow-up, with 66,909 person-years, 791 deaths occurred. At baseline, the weighted prevalence of UACR ≥ 30mg/g and eGFRCKD-EPI 2009 < 60 ml/min/1.73m2 was 6.6% and 1.6%, respectively. The risk for death was increased with higher UACR (10-30 (HR 1.6 [1.2-2.1]), 30-300 (2.4 [1.8-3.1]), and ≥300 (HR: 6.0 [3.8-9.4]) relative to UACR < 10 mg/g). Risk for mortality also higher with lower eGFRCKD-EPI 2009 (44-30 (HR: HR 4.5 [2.5-8.3]) and <30 (HR: 7.0 [3.7-13.0]), relative to 104-90 ml/min). PAF for mortality due to UACR ≥30 mg/g and eGFRCKD-EPI 2009 < 45 ml/min/1.73m2 were 24.4% and 13.4%, respectively.ConclusionsSingle-time point assessment of UACR ≥30 mg/g or eGFRCKD-EPI 2009 < 45 ml/min/1.73m2 portends higher mortality risk among urban South Asians. Since albuminuria is common and generally associated with accelerated decline in GFR, screening and targeted efforts to reduce albuminuria are warranted.","journal":"Kidney International Reports","year":2024,"id":464106,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9199,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":234901,"name":"Shuchi Anand","orcid":"0000-0002-9892-8477","position":1,"is_corresponding":false},{"id":344911,"name":"Dimple Kondal","orcid":"0000-0002-1417-9510","position":2,"is_corresponding":false},{"id":234903,"name":"Jialin Han","orcid":"0000-0001-5731-8974","position":3,"is_corresponding":false},{"id":234902,"name":"Maria E. Montez‐Rath","orcid":"0000-0001-5154-2182","position":4,"is_corresponding":false},{"id":22946,"name":"Mohammed K. Ali","orcid":"0000-0001-7266-2503","position":5,"is_corresponding":false},{"id":337637,"name":"Shivani A. Patel","orcid":"0000-0003-0082-5857","position":6,"is_corresponding":false},{"id":398298,"name":"Kavita Singh","orcid":"0000-0003-4330-666X","position":7,"is_corresponding":false},{"id":417669,"name":"Roopa Shivashankar","orcid":"0000-0002-4361-9423","position":8,"is_corresponding":false},{"id":1295141,"name":"R.M. Anjana","orcid":null,"position":9,"is_corresponding":false},{"id":519592,"name":"Ruby Gupta","orcid":"0000-0002-8487-6004","position":10,"is_corresponding":false},{"id":337639,"name":"Sailesh Mohan","orcid":"0000-0003-1853-3596","position":11,"is_corresponding":false},{"id":11025,"name":"Glenn M. Chertow","orcid":"0000-0002-7599-0534","position":12,"is_corresponding":false},{"id":38951,"name":"Viswanathan Mohan","orcid":"0000-0001-5038-6210","position":13,"is_corresponding":false},{"id":22843,"name":"Nikhil Tandon","orcid":"0000-0003-4604-1986","position":14,"is_corresponding":false},{"id":245134,"name":"K.M. Venkat Narayan","orcid":"0000-0001-8621-5405","position":15,"is_corresponding":false},{"id":23230,"name":"Dorairaj Prabhakaran","orcid":"0000-0002-3172-834X","position":16,"is_corresponding":false},{"id":365427,"name":"Ram Jagannathan","orcid":null,"position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-19T02:04:37.468651Z","pmid":"39156172","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}