{"doi":"10.1016/j.ekir.2023.11.030","title":"Longitudinal Trajectories of Biomarkers of Kidney Tubular Function in Type 1 Diabetes","abstract":"Introduction: Tubular biomarkers may shed insight into progression of kidney tubulointerstitial pathology complementary to traditional measures of glomerular function and damage. Methods: We examined trajectories of tubular biomarkers in the Diabetes Control and Complications Trial and the Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC Study) of type 1 diabetes (T1D). Biomarkers were measured in a subset of 220 participants across 7 time points over 26 years. Measurements included the following: kidney injury molecule 1 (KIM-1), soluble tumor necrosis factor 1 (sTNFR1) in serum or plasma, epidermal growth factor (EGF), monocyte chemoattractant protein-1 (MCP1) in timed urine, and a composite tubular secretion score. We described biomarker trajectories and examined how these were affected by intensive glucose-lowering therapy and glycemia. Results: and 90% of participants had a urinary albumin excretion rate (AER) <30 mg/24h. Mean changes in biomarkers over time (percent/decade) were: KIM-1: 27.3% (95% confidence interval [CI]: 21.4-33.5), sTNFR1: 16.9% (14.5-19.3), MCP1: 18.4% (8.9-28.8), EGF: -13.5% (-16.7 to -10.1), EGF-MCP1 ratio: -26.9% (-32.2 to -21.3), and tubular secretion score -0.9% (-1.8 to 0.0), versus -12.0% (CI: -12.9 to -11.1) for eGFR and 10.9% (2.5-20.1) for AER. Intensive versus conventional glucose-lowering therapy was associated with slower increase in sTNFR1 (relative difference in change: 0.94 [0.90-0.98]). Higher HbA1c was associated with faster increases in sTNFR1 (relative difference in change: 1.06 per 1% higher HbA1c [1.05-1.08]) and KIM-1 (1.09 [1.05-1.14]). Conclusion: Among participants with T1D and normal eGFR at baseline, kidney tubular biomarkers changed significantly over long-term follow-up. Hyperglycemia was associated with larger increases in serum or plasma sTNFR1 and KIM-1, when followed-up longitudinally.","journal":"Kidney International Reports","year":2024,"id":461897,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9285,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":725470,"name":"Xiaoyu Gao","orcid":"0000-0003-0633-8996","position":1,"is_corresponding":false},{"id":333919,"name":"Ionut Bebu","orcid":"0000-0002-4944-7968","position":2,"is_corresponding":false},{"id":525009,"name":"Jesse C. Seegmiller","orcid":"0000-0003-2542-6502","position":3,"is_corresponding":false},{"id":726317,"name":"Gayle M. Lorenzi","orcid":null,"position":4,"is_corresponding":false},{"id":231208,"name":"Bruce A. Perkins","orcid":"0000-0002-5885-0046","position":5,"is_corresponding":false},{"id":231205,"name":"Amy B. Karger","orcid":"0000-0002-2781-3824","position":6,"is_corresponding":false},{"id":1291367,"name":"Valerie L. Arends","orcid":null,"position":7,"is_corresponding":false},{"id":1531,"name":"Andrew D. Paterson","orcid":"0000-0002-9169-118X","position":8,"is_corresponding":false},{"id":231207,"name":"Mark E. Molitch","orcid":"0000-0002-8492-3587","position":9,"is_corresponding":false},{"id":231201,"name":"Ian H. de Boer","orcid":"0000-0003-1571-7592","position":10,"is_corresponding":false},{"id":481576,"name":"Christine P. Limonte","orcid":"0000-0002-9162-7428","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-19T02:04:16.410510Z","pmid":"38707816","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}