{"doi":"10.1016/j.ekir.2023.09.026","title":"TRPC6 Inhibitor BI 764198 in Focal Segmental Glomerulosclerosis: Phase 2 Study Design","abstract":null,"journal":"Kidney International Reports","year":2023,"id":601755,"datarank":0.49983067652628066,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.0,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":5968,"name":"Matthias Kretzler","orcid":"0000-0003-4064-0582","position":1,"is_corresponding":false},{"id":1543005,"name":"Hailey E. Desmond","orcid":null,"position":2,"is_corresponding":false},{"id":1543006,"name":"Wansuk Choi","orcid":null,"position":3,"is_corresponding":false},{"id":1543007,"name":"Raymond C. Manuel","orcid":null,"position":4,"is_corresponding":false},{"id":1543008,"name":"Nima Soleymanlou","orcid":null,"position":5,"is_corresponding":false},{"id":742453,"name":"Howard Trachtman","orcid":"0009-0006-7778-292X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"TRPC6 Inhibitor BI 764198 in Focal Segmental Glomerulosclerosis: Phase 2 Study Design","abstract":"Focal segmental glomerulosclerosis (FSGS), a leading glomerular cause of kidney failure, is a histological pattern characterized by podocyte injury and depletion.1 FSGS is found in 20–30% of adults with nephrotic syndrome and up to 20% of patients receiving dialysis.2,S1 FSGS can be broadly categorized into four causative classifications: primary (idiopathic), secondary (adaptive), familial (genetic), and of unknown cause.1,3,S2 Depending on patient selection and region, genetic variants have been reported in up to 14% of individuals with adult-onset FSGS.","is_dataset_classified":null,"base_score":3.295836866004329,"endowment":3.295836866004329,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38106603","pmcid":"PMC10719596","openalex_id":"https://openalex.org/W4387165454","authors":[],"funders":[{"funder_name":"Boehringer Ingelheim","grant_id":"","title":null}],"total_grants":1,"fwci":3.9342,"citation_percentile":0.94911077,"influential_citations":0,"citation_trend":[{"year":2024,"count":4},{"year":2025,"count":17},{"year":2026,"count":5}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"http://www.kireports.org/article/S246802492301519X/pdf","host_type":"journal"},{"url":"http://www.kireports.org/article/S246802492301519X/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S246802492301519X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S246802492301519X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ekir.2023.09.026","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38106603","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10719596","host_type":"repository"},{"url":"https://doaj.org/article/7d2ce554e6144d519f8547492ad6b5f7","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10719596/pdf/main.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10719596","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10719596?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Renal Diseases and Glomerulopathies","Chronic Kidney Disease and Diabetes","Celiac Disease Research and Management"],"mesh_terms":[],"keywords":["Focal segmental glomerulosclerosis","Medicine","TRPC6","Nephrotic syndrome","Podocyte","Glomerulosclerosis","Dialysis","Kidney","Pathology","Glomerulonephritis","Internal medicine","Proteinuria","Receptor","Podocytes","Research Design","Phase 2 Clinical Trial","Trpc6 Cation Channel"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"eudract"},{"name":"nct"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T17:21:19.468576Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}