{"doi":"10.1016/j.ekir.2023.02.564","title":"WCN23-1242 Genetic interaction between XBP1 and Pkd1 modulates ADPKD progression","abstract":"Figure 1.Effects of MET+KM_drug on PKD1 null cell proliferation.(a) Schematic depicting how drug-loaded KMs are combined with MET and incubated with PKD1 null cells cultured in 96-well plates for this study.Cells were treated with PBS, empty KMs, MET alone, free drugs alone, MET+free drugs, KM_drugs alone, and MET+KM_drugs for 48 h, where drugs are (b) SAL, (c) OCT, (d) BAR, (e) RAP, (f) TOL, and (g) PIO.Cell proliferation was determined using a MTS assay, normalized to PBS treatment.*P # 0.05, **P # 0.01, ****P # 0.0001.Conclusions: Together, we show drug synergy using drug-loaded nanoparticles and free MET for the first time and present a novel nanomedicine-based combinatorial therapeutic approach for ADPKD with enhanced efficacy.","journal":"Kidney International Reports","year":2023,"id":403842,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9508,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1181798,"name":"C. Pioppini","orcid":null,"position":1,"is_corresponding":false},{"id":1181799,"name":"R. Bhardwaj","orcid":null,"position":2,"is_corresponding":false},{"id":1181800,"name":"E. Duygu","orcid":null,"position":3,"is_corresponding":false},{"id":1181801,"name":"T. Hollmann","orcid":null,"position":4,"is_corresponding":false},{"id":1181802,"name":"S. Somlo","orcid":null,"position":5,"is_corresponding":false},{"id":1181803,"name":"S. Fedeles","orcid":null,"position":6,"is_corresponding":false},{"id":1181797,"name":"M. Krappitz","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T01:20:40.264741Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}