{"doi":"10.1016/j.ekir.2022.07.003","title":"Efficacy, Safety, and Tolerability of Oral Furosemide Among Patients Receiving Hemodialysis: A Pilot Study","abstract":"IntroductionDiuretic use may reduce volume-related complications in hemodialysis. We evaluated the efficacy, safety, and tolerability of furosemide in patients with hemodialysis-dependent kidney failure.MethodsWe conducted an open label, single-arm, 18-week, dose titration pilot study of oral furosemide (maximum dose 320 mg/day) among patients receiving maintenance hemodialysis who reported at least 1 cup of urine output per day. The primary efficacy outcome was an increase from baseline to a specified threshold of 24-hour urine volume, with the threshold based on baseline urine volume (<200 ml/day vs. ≥200 ml/day). Safety outcomes included hypokalemia and hypomagnesemia, and tolerability was assessed by prespecified patient-reported symptoms.ResultsOf the 39 participants, 28 (72%) received the expected furosemide dose, 3 (8%) underwent dose reduction, 5 (12%) discontinued furosemide without dose reduction, and 3 (8%) underwent dose reduction and subsequently discontinued furosemide. The median (quartile 1, quartile 3) baseline 24-hour urine volume was 290 ml (110, 740), and the maximum, average daily study furosemide dose ranged from 69 mg/day to 320 mg/d. The urine output efficacy outcome was met by 12 (33%), 11 (33%), and 7 (22%) participants at weeks 5, 12, and 18, respectively, in the intention-to-treat analysis, and by 12 (39%), 9 (35%), and 7 (28%) participants at weeks 5, 12, and 18, respectively, in the on-treatment analysis. There were no electrolyte, furosemide level, or patient-reported hearing change safety events.ConclusionFurosemide was generally safe and well tolerated, but only one-third of participants met the efficacy definition at week 5. The clinical importance of the efficacy findings is uncertain.","journal":"Kidney International Reports","year":2022,"id":257662,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9537,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":243737,"name":"Magdalene M. Assimon","orcid":null,"position":1,"is_corresponding":false},{"id":367843,"name":"Matthew J. Tugman","orcid":null,"position":2,"is_corresponding":false},{"id":367844,"name":"Julia H. Narendra","orcid":null,"position":3,"is_corresponding":false},{"id":908156,"name":"Simran Singh","orcid":"0009-0000-4118-9792","position":4,"is_corresponding":false},{"id":908157,"name":"Wanting Jin","orcid":"0000-0002-3258-8828","position":5,"is_corresponding":false},{"id":408593,"name":"Quefeng Li","orcid":"0000-0003-0707-2763","position":6,"is_corresponding":false},{"id":54242,"name":"Nisha Bansal","orcid":"0000-0002-9583-8628","position":7,"is_corresponding":false},{"id":444905,"name":"Thomas H. Hostetter","orcid":null,"position":8,"is_corresponding":false},{"id":277168,"name":"Laura M. Dember","orcid":"0000-0002-9735-7473","position":9,"is_corresponding":false},{"id":241192,"name":"Jennifer E. Flythe","orcid":"0000-0003-4596-8536","position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":null,"created_at":"2026-07-19T00:25:34.440699Z","pmid":"36217511","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}