{"doi":"10.1016/j.ekir.2021.01.004","title":"Prognostic Value of Fibroblast Growth Factor 23 in Autosomal Dominant Polycystic Kidney Disease","abstract":"INTRODUCTION: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst growth and a loss of functioning renal mass, but a decline in glomerular filtration rate (GFR) and onset of end-stage renal disease (ESRD) occur late in the disease course. There is therefore a great need for early prognostic biomarkers in this disorder. METHODS: We measured baseline serum fibroblast growth factor 23 (FGF23) levels in 192 patients with ADPKD from the Consortium for Radiologic Imaging Studies of PKD (CRISP) cohort that were followed for a median of 13 years and tested the association between FGF23 levels and change over time in height-adjusted total kidney volume (htTKV), GFR, and time to the composite endpoints of ESRD, death, and doubling of serum creatinine. RESULTS: = 0.03). CONCLUSION: FGF23 is a prognostic biomarker for disease progression and clinically important outcomes in ADPKD, and has additive value to established imaging and genetic biomarkers.","journal":"Kidney International Reports","year":2021,"id":180038,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9616,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":478692,"name":"Pengcheng Lu","orcid":"0000-0001-5058-0101","position":1,"is_corresponding":false},{"id":296471,"name":"Jonathan D. Mahnken","orcid":null,"position":2,"is_corresponding":false},{"id":363544,"name":"Jason R. Stubbs","orcid":"0000-0003-4580-5745","position":3,"is_corresponding":false},{"id":363539,"name":"Shiqin Zhang","orcid":"0000-0002-9847-5658","position":4,"is_corresponding":false},{"id":299686,"name":"Darren P. Wallace","orcid":"0000-0003-4616-7669","position":5,"is_corresponding":false},{"id":728464,"name":"Jared J. Grantham","orcid":"0000-0003-1450-7438","position":6,"is_corresponding":false},{"id":441227,"name":"Arlene B. Chapman","orcid":"0000-0002-6030-8694","position":7,"is_corresponding":false},{"id":232142,"name":"Vicente E. Torres","orcid":"0000-0003-2008-1576","position":8,"is_corresponding":false},{"id":318231,"name":"Peter C. Harris","orcid":"0000-0002-5304-6593","position":9,"is_corresponding":false},{"id":729210,"name":"Kyongtae Ty Bae","orcid":null,"position":10,"is_corresponding":false},{"id":351882,"name":"Douglas Landsittel","orcid":"0000-0002-0452-304X","position":11,"is_corresponding":false},{"id":728465,"name":"Frederic F. Rahbari-Oskoui","orcid":"0000-0001-8933-4880","position":12,"is_corresponding":false},{"id":305251,"name":"Michal Mrug","orcid":"0000-0001-8981-1843","position":13,"is_corresponding":false},{"id":728466,"name":"William M. Bennett","orcid":"0000-0003-2916-1927","position":14,"is_corresponding":false},{"id":270870,"name":"Alan S.L. Yu","orcid":"0000-0002-1776-2533","position":15,"is_corresponding":false},{"id":478690,"name":"Mireille El Ters","orcid":"0000-0002-8845-9849","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:47:53.089578Z","pmid":"33912745","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}