{"doi":"10.1016/j.ekir.2020.03.020","title":"<i>APOL1</i> Kidney-Risk Variants Induce Mitochondrial Fission.","abstract":"INTRODUCTION: -nephropathy. METHODS: A global gene expression analysis was performed in human primary renal tubule cell lines derived from 50 African American individuals. Follow-up gene knock out, cell-based rescue, and microscopy experiments were performed. RESULTS: G0, G1, and G2 were created; G0 cells appeared to promote mitochondrial fusion, whereas G1 and G2 induced mitochondrial fission. The mitochondrial dynamic regulator Mdivi-1 significantly preserved cell viability and mitochondrial cristae structure and reversed mitochondrial fission induced by overexpression of G1 and G2. CONCLUSION: -nephropathy.","journal":"PubMed","year":2020,"id":91725,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9632,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":349012,"name":"Hannah C. Ainsworth","orcid":"0000-0003-1185-0695","position":1,"is_corresponding":false},{"id":460318,"name":"James A. Snipes","orcid":null,"position":2,"is_corresponding":false},{"id":369541,"name":"Mariana Murea","orcid":"0000-0003-3217-1691","position":3,"is_corresponding":false},{"id":442686,"name":"Young A. Choi","orcid":null,"position":4,"is_corresponding":false},{"id":130814,"name":"Carl D. Langefeld","orcid":null,"position":5,"is_corresponding":false},{"id":299668,"name":"John S. Parks","orcid":"0000-0002-5227-8915","position":6,"is_corresponding":false},{"id":459203,"name":"Manish S. Bharadwaj","orcid":"0000-0001-5360-8560","position":7,"is_corresponding":false},{"id":383995,"name":"Jeff W. Chou","orcid":null,"position":8,"is_corresponding":false},{"id":441647,"name":"Ashok K. Hemal","orcid":"0000-0001-8270-341X","position":9,"is_corresponding":false},{"id":460319,"name":"Snežana Petrović","orcid":null,"position":10,"is_corresponding":false},{"id":460320,"name":"Ann L. Craddock","orcid":null,"position":11,"is_corresponding":false},{"id":459204,"name":"Dongmei Cheng","orcid":"0000-0002-4638-0884","position":12,"is_corresponding":false},{"id":324562,"name":"Gregory A. Hawkins","orcid":null,"position":13,"is_corresponding":false},{"id":173915,"name":"Lance D. Miller","orcid":"0000-0003-3799-2528","position":14,"is_corresponding":false},{"id":460321,"name":"Pamela J Hicks","orcid":null,"position":15,"is_corresponding":false},{"id":448729,"name":"Moin A. Saleem","orcid":"0000-0002-9808-4518","position":16,"is_corresponding":false},{"id":342446,"name":"Jasmin Divers","orcid":"0000-0003-0120-7620","position":17,"is_corresponding":false},{"id":459205,"name":"Anthony Molina","orcid":"0000-0002-5786-4622","position":18,"is_corresponding":false},{"id":90098,"name":"Barry I. Freedman","orcid":"0000-0003-0275-5530","position":19,"is_corresponding":false},{"id":459202,"name":"Lijun Ma","orcid":"0000-0002-7763-7793","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-18T22:29:21.932251Z","pmid":"32518871","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}