{"doi":"10.1016/j.ejps.2025.107016","title":"Optimized PLGA encapsulated SA-2 nanosuspension exhibits sustained intraocular pressure reduction in the mouse microbead occlusion model of ocular hypertension","abstract":"Elevated intraocular pressure (IOP) is implicated in the structural and functional damage to the retinal ganglion cells (RGCs) in primary open-angle glaucoma (POAG). Topical IOP lowering agents provide short-term relief, necessitating frequent dosing. Moreover, non-adherence to frequent eyedrops administration contributes significantly to visual field loss and worsens the disease outcome. We optimized the poly (lactic-co-glycolic acid) (PLGA) nanoparticles encapsulation of hybrid antioxidant-nitric oxide donor SA-2 (SA-2NP), investigated its bioavailability, duration of IOP lowering efficacy, and effects on retinal function in the microbead model of ocular hypertension (OHT). SA-2 was bioavailable in the anterior and posterior segments after 1, 8, and 24 h post-single topical eyedrop administration. SA-2NP significantly lowered IOP (∼25-34%) and preserved the RGC function after weekly eyedrop administration for 3 weeks in C57BL/6J mice. In conclusion, the optimized SA-2NP formulation demonstrated optimal bioavailability, ocular safety, and prolonged IOP-lowering efficacy in the mouse microbead occlusion model of OHT.","journal":"European Journal of Pharmaceutical Sciences","year":2025,"id":529877,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9492,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1409677,"name":"Biddut DebNath","orcid":null,"position":1,"is_corresponding":false},{"id":1409223,"name":"Jennifer H. Pham","orcid":"0000-0003-0965-3625","position":2,"is_corresponding":false},{"id":1409224,"name":"Gretchen A. Johnson","orcid":"0000-0001-7330-269X","position":3,"is_corresponding":false},{"id":1409225,"name":"Wei Zhang","orcid":"0000-0002-7527-2217","position":4,"is_corresponding":false},{"id":980628,"name":"Amalendu P. Ranjan","orcid":"0000-0002-3641-7751","position":5,"is_corresponding":false},{"id":565694,"name":"Dorota L. Stankowska","orcid":"0000-0002-2541-6649","position":6,"is_corresponding":false},{"id":790054,"name":"Suchismita Acharya","orcid":"0000-0001-5098-5555","position":7,"is_corresponding":false},{"id":790052,"name":"Charles E. Amankwa","orcid":"0000-0002-1120-7053","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T02:51:01.235017Z","pmid":"39827971","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}