{"doi":"10.1016/j.ejphar.2023.175670","title":"Hesperidin may improve depressive symptoms by binding NLRP3 and influencing the pyroptosis pathway in a rat model","abstract":null,"journal":"European Journal of Pharmacology","year":2023,"id":591972,"datarank":0.8502036094652915,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.3614891287620691,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.3614891287620691,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":25,"citers_with_citation_signal":20,"citers_with_endowment":20,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":934797,"name":"Dong Yang","orcid":"0000-0002-1971-7349","position":1,"is_corresponding":false},{"id":1514708,"name":"Kechao Nie","orcid":null,"position":2,"is_corresponding":false},{"id":1514709,"name":"Ruoheng Lin","orcid":null,"position":3,"is_corresponding":false},{"id":1514710,"name":"Luqi Peng","orcid":null,"position":4,"is_corresponding":false},{"id":1514711,"name":"Xuhui Zhou","orcid":null,"position":5,"is_corresponding":false},{"id":736002,"name":"Mei Zhang","orcid":"0000-0002-4284-555X","position":6,"is_corresponding":false},{"id":799071,"name":"Ying Zeng","orcid":"0000-0002-2797-5559","position":7,"is_corresponding":false},{"id":1514712,"name":"Lini Liu","orcid":null,"position":8,"is_corresponding":false},{"id":332615,"name":"Wei Huang","orcid":"0000-0002-1775-6512","position":9,"is_corresponding":false},{"id":1386798,"name":"Hui Cao","orcid":"0009-0004-2594-1015","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Hesperidin may improve depressive symptoms by binding NLRP3 and influencing the pyroptosis pathway in a rat model","abstract":"<h4>Objective</h4>Major depressive disorder (MDD) is a debilitating psychiatric disorder which is common and endangers human physical and mental health. Studies have shown that hesperidin could improve the symptoms of depression with unclear mechanisms.<h4>Method</h4>In this study, hesperidin was administered to chronic unpredictable mild stress (CUMS) depressed mice before behavioral test, network pharmacology analysis, RNA expression microarray analysis, pathway validation and molecular docking experiments.<h4>Results</h4>we found that hesperidin intervention could significantly improve the depressive symptoms and downregulate the expression level of pyroptosis pathway including caspase 1 (Casp1), interleukin 18 (IL18), interleukin-1β (IL-1β) and NOD-like receptor thermal protein domain associated protein 3 (NLRP3). In addition, we found that hesperidin could possibly bind to NLRP3.<h4>Conclusions</h4>Our study demonstrated that hesperidin had huge potential as anti-depressive neuroprotectant, and may play a role in treating MDD by regulating NLRP3-mediated pyroptosis.","is_dataset_classified":null,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37169143","pmcid":null,"openalex_id":"https://openalex.org/W4375945424","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"81303098","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81774281","title":null},{"funder_name":"Natural Science Foundation of Hunan Province","grant_id":"2019JJ40509","title":null},{"funder_name":"Natural Science Foundation of Hunan Province","grant_id":"2019JJ80026","title":null},{"funder_name":"Natural Science Foundation of Hunan Province","grant_id":"2023JJ30888","title":null}],"total_grants":5,"fwci":2.3406,"citation_percentile":0.89441477,"influential_citations":0,"citation_trend":[{"year":2024,"count":13},{"year":2025,"count":8},{"year":2026,"count":4}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0014299923001814?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0014299923001814?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ejphar.2023.175670","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37169143","host_type":"repository"}],"fields_of_study":["Inflammasome and immune disorders","Tryptophan and brain disorders","Natural Compound Pharmacology Studies"],"mesh_terms":["Pyroptosis","NLR Family, Pyrin Domain-Containing 3 Protein","Animals","Depression","Depressive Disorder, Major","Major Depressive Disorder","Hesperidin","Humans","Caspase 1","Rats","Inflammasomes","Molecular Docking Simulation"],"keywords":["Hesperidin","Pyroptosis","Major depressive disorder","Pharmacology","Medicine","Bioinformatics","Chemistry","Receptor","Psychiatry","Biology","Inflammasome","Internal medicine","Nlrp3"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T11:38:00.183187Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}