{"doi":"10.1016/j.ejphar.2016.11.031","title":"Inhibition of the potassium channel K Ca 3.1 by senicapoc reverses tactile allodynia in rats with peripheral nerve injury","abstract":null,"journal":"European Journal of Pharmacology","year":2017,"id":606070,"datarank":0.5244761342199721,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"self_citation_contribution":0.5244761342199721,"citation_network_contribution":0.0,"self_endowment_contribution":0.5244761342199721,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1555656,"name":"Tanzilya Khayrullina","orcid":null,"position":1,"is_corresponding":false},{"id":527496,"name":"Hong Zhang","orcid":"0000-0002-6417-8399","position":2,"is_corresponding":false},{"id":37329,"name":"Scott Davis","orcid":"0000-0001-5320-4435","position":3,"is_corresponding":false},{"id":1555658,"name":"Shaun M. Fallon","orcid":null,"position":4,"is_corresponding":false},{"id":1555659,"name":"Manuel Cajina","orcid":null,"position":5,"is_corresponding":false},{"id":1555661,"name":"Megan E. Nattini","orcid":null,"position":6,"is_corresponding":false},{"id":356388,"name":"Andrew Hu","orcid":"0000-0002-9472-4768","position":7,"is_corresponding":false},{"id":7195,"name":"Hua Zhou","orcid":"0000-0001-6397-3203","position":8,"is_corresponding":false},{"id":1555664,"name":"Suresh Babu Poda","orcid":null,"position":9,"is_corresponding":false},{"id":1555665,"name":"Stevin Zorn","orcid":null,"position":10,"is_corresponding":false},{"id":1555666,"name":"Gamini Chandrasena","orcid":null,"position":11,"is_corresponding":false},{"id":1555667,"name":"Elena Dale","orcid":null,"position":12,"is_corresponding":false},{"id":1555669,"name":"Brian Cambpell","orcid":null,"position":13,"is_corresponding":false},{"id":1555671,"name":"Lars Christian Biilmann Rønn","orcid":null,"position":14,"is_corresponding":false},{"id":909023,"name":"Gordon Munro","orcid":"0000-0002-7917-5748","position":15,"is_corresponding":false},{"id":1555673,"name":"Thomas Mӧller","orcid":null,"position":16,"is_corresponding":false},{"id":1555654,"name":"Roland G.W. Staal","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Inhibition of the potassium channel K Ca 3.1 by senicapoc reverses tactile allodynia in rats with peripheral nerve injury","abstract":"Neuropathic pain is a debilitating, chronic condition with a significant unmet need for effective treatment options. Recent studies have demonstrated that in addition to neurons, non-neuronal cells such as microglia contribute to the initiation and maintenance of allodynia in rodent models of neuropathic pain. The Ca<sup>2+</sup>- activated K<sup>+</sup> channel, K<sub>Ca</sub>3.1 is critical for the activation of immune cells, including the CNS-resident microglia. In order to evaluate the role of K<sub>Ca</sub>3.1 in the maintenance of mechanical allodynia following peripheral nerve injury, we used senicapoc, a stable and highly potent K<sub>Ca</sub>3.1 inhibitor. In primary cultured microglia, senicapoc inhibited microglial nitric oxide and IL-1β release. In vivo, senicapoc showed high CNS penetrance and when administered to rats with peripheral nerve injury, it significantly reversed tactile allodynia similar to the standard of care, gabapentin. In contrast to gabapentin, senicapoc achieved efficacy without any overt impact on locomotor activity. Together, the data demonstrate that the K<sub>Ca</sub>3.1 inhibitor senicapoc is effective at reducing mechanical hypersensitivity in a rodent model of peripheral nerve injury.","is_dataset_classified":null,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27876619","pmcid":null,"openalex_id":"https://openalex.org/W2555458334","authors":[],"funders":[],"total_grants":0,"fwci":2.9922,"citation_percentile":0.91243314,"influential_citations":0,"citation_trend":[{"year":2017,"count":4},{"year":2018,"count":4},{"year":2019,"count":8},{"year":2020,"count":2},{"year":2021,"count":2},{"year":2022,"count":4},{"year":2023,"count":3},{"year":2024,"count":3},{"year":2025,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0014299916307312?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0014299916307312?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ejphar.2016.11.031","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27876619","host_type":"repository"}],"fields_of_study":["Pain Mechanisms and Treatments","Pharmacological Effects of Natural Compounds","Ion channel regulation and function"],"mesh_terms":["Acetamides","Animals","Cricetulus","Dose-Response Relationship, Drug","Drug Stability","Cricetinae","Humans","Hyperalgesia","Locomotion","Potassium","Triphenylmethyl Compounds","Trityl Compounds","CHO Cells","Microglia","Potassium Channel Blockers","Rats","Intermediate-Conductance Calcium-Activated Potassium Channels","Peripheral Nerve Injuries"],"keywords":["Allodynia","Peripheral nerve injury","Neuropathic pain","Gabapentin","Microglia","Nerve injury","Medicine","Pharmacology","Peripheral","Nitric oxide","Peripheral neuropathy","Neuroscience","Anesthesia","Hyperalgesia","Sciatic nerve","Endocrinology","Inflammation","Internal medicine","Receptor","Pathology","Nociception","Biology","calcium-activated potassium channel","Von Frey","Chronic Constriction Injury","Kcnn4","Tactile Allodynia","K(ca)3.1","Ica-17043","Senicapoc"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T03:50:47.604507Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}