{"doi":"10.1016/j.ejphar.2007.01.083","title":"dextro-Morphine attenuates the morphine-produced conditioned place preference via the sigma1 receptor activation in the rat","abstract":null,"journal":"European Journal of Pharmacology","year":2007,"id":603775,"datarank":0.44166584687496613,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.0,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1548895,"name":"Emma T. Schwasinger","orcid":null,"position":1,"is_corresponding":false},{"id":535656,"name":"Maia Terashvili","orcid":null,"position":2,"is_corresponding":false},{"id":121370,"name":"Leon F. Tseng","orcid":null,"position":3,"is_corresponding":false},{"id":467035,"name":"Hsiang-en Wu","orcid":"0000-0003-4492-2077","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"dextro-Morphine attenuates the morphine-produced conditioned place preference via the sigma1 receptor activation in the rat","abstract":"An unbiased conditioned place preference paradigm was used to evaluate the effect of dextro-morphine on the morphine-produced reward in male CD rats. Morphine sulfate (1-10 mg/kg) given intraperitoneally dose-dependently produced the conditioned place preference. Pretreatment with dextro-morphine at a dose from 0.1 to 3 microg/kg given subcutaneously dose-dependently attenuated the morphine-produced conditioned place preference. However, dextro-morphine at a higher dose 100 microg/kg did not affect the morphine-produced conditioned place preference. Thus, dextro-morphine pretreatment induces a U-shaped dose-response curve for attenuating the morphine-produced conditioned place preference. The attenuation of the morphine-produced conditioned place preference was reversed by the pretreatment with the sigma(1) receptor antagonist BD1047 (N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide. dextro-Morphine or BD1047 given alone did not affect the baseline place conditioning. It is concluded that dextro-morphine attenuated the morphine-produced conditioned place preference via the sigma(1) receptor activation.","is_dataset_classified":null,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17335800","pmcid":"PMC1936970","openalex_id":"https://openalex.org/W1966538847","authors":[],"funders":[{"funder_name":"NIDA NIH HHS","grant_id":"R01 DA012588","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"DA12588","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"K01 DA024751","title":null}],"total_grants":3,"fwci":0.7994,"citation_percentile":0.69706359,"influential_citations":0,"citation_trend":[{"year":2013,"count":2},{"year":2016,"count":2},{"year":2017,"count":1},{"year":2020,"count":1},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"green","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1936970","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1936970","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0014299907001495?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0014299907001495?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ejphar.2007.01.083","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17335800","host_type":"repository"}],"fields_of_study":["Pharmacological Receptor Mechanisms and Effects","Neuropeptides and Animal Physiology","Receptor Mechanisms and Signaling"],"mesh_terms":["Sigma-1 Receptor","Analgesics, Opioid","Analysis of Variance","Animals","Conditioning, Operant","Dose-Response Relationship, Drug","Ethylenediamines","Injections, Intraperitoneal","Injections, Subcutaneous","Male","Morphine","Reward","Stereoisomerism","Receptors, sigma","Rats"],"keywords":["Conditioned place preference","Morphine","Antagonist","Chemistry","Conditioning","Pharmacology","Medicine","Receptor","Internal medicine","Mathematics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T22:42:06.837765Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}