{"doi":"10.1016/j.ejogrb.2026.115271","title":"Fetal sex-specific relations of human placental peroxisome proliferator-activated receptors gamma (PPAR-γ) expression with fetoplacental growth","abstract":null,"journal":"European Journal of Obstetrics &amp; Gynecology and Reproductive Biology","year":2026,"id":657775,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1717111,"name":"Ceera Manikandan","orcid":null,"position":1,"is_corresponding":false},{"id":1717112,"name":"Gayatri Ravikumar","orcid":null,"position":2,"is_corresponding":false},{"id":1717113,"name":"Julian Crasta","orcid":null,"position":3,"is_corresponding":false},{"id":451005,"name":"Tinku Thomas","orcid":"0000-0002-1786-6076","position":4,"is_corresponding":false},{"id":1717115,"name":"Annamma Thomas","orcid":null,"position":5,"is_corresponding":false},{"id":344133,"name":"Anura V. Kurpad","orcid":"0000-0001-7998-2438","position":6,"is_corresponding":false},{"id":648742,"name":"Pratibha Dwarkanath","orcid":null,"position":7,"is_corresponding":false},{"id":1717118,"name":"Arpita Mukhopadhyay","orcid":"0000-0001-8260-5385","position":8,"is_corresponding":false},{"id":1717110,"name":"Prachi Kochhar","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Fetal sex-specific relations of human placental peroxisome proliferator-activated receptors gamma (PPAR-γ) expression with fetoplacental growth","abstract":"<h4>Objective</h4>Peroxisome proliferator-activated receptors gamma (PPAR-γ) regulates lipid storage and is involved in placental trophoblast differentiation and placental vasculature development. In this case-control study, associations between maternal, placental and neonatal parameters and placental PPAR-γ transcript abundance has been investigated in a set of well characterized small (SGA) and appropriate for gestational age (AGA) births.<h4>Methods</h4>From 39 SGA and 51 AGA singleton pregnancies, placental samples were collected. Information on maternal and newborn anthropometry and clinical variables were recorded. Placental transcript abundance of PPAR-γ, with respect to housekeeping genes ACTB, YWHAZ and B2M, was evaluated using realtime quantitative PCR. Associations between maternal, placental and neonatal parameters and placental PPAR-γ transcript abundance was evaluated and levels of placental PPAR-γ transcript abundance was compared between SGA and AGA births.<h4>Results</h4>Placental PPAR-γ transcript abundance was associated negatively with birth weight in all 90 births evaluated (β = -21.764, P = 0.026), in SGA births (n = 39, β = -19.533, P = 0.032) and in female AGA births (n = 29, β = -22.778, P = 0.041). Placental PPAR-γ transcript abundance was associated with placental length in all 90 births evaluated (β = -0.098, P = 0.005) and in SGA births (n = 39, β = -0.084, P = 0.032) and with placental breadth (n = 90, β = -0.095, P = 0.011). Female SGA placentae (n = 16) exhibited higher levels of placental PPAR-γ transcript levels compared to female AGA placentae (n = 29; P = 0.042).<h4>Conclusion</h4>Findings from this study indicate that fetal sex modulates the relations between placental PPAR-γ transcript abundance and birth weight. Repression of placental PPAR-γ expression was associated with better fetal growth, amongst SGA births of both sexes, and amongst female AGA births. The underlying mechanisms need to be addressed in future studies.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"42364286","pmcid":null,"openalex_id":"https://openalex.org/W7165526538","authors":[],"funders":[{"funder_name":"Government of India Department of Biotechnology","grant_id":"","title":null},{"funder_name":"DBT/Wellcome Trust India Alliance","grant_id":"","title":null}],"total_grants":2,"fwci":0.0,"citation_percentile":0.66594096,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0301211526003398?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0301211526003398?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ejogrb.2026.115271","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/42364286","host_type":"repository"}],"fields_of_study":["Peroxisome Proliferator-Activated Receptors","Pregnancy and preeclampsia studies","Gestational Diabetes Research and Management","Humans","Female","PPAR gamma","Pregnancy","Placenta","Adult","Infant, Small for Gestational Age","Birth Weight","Fetal Development","Infant, Newborn","Male","Case-Control Studies","Sex Factors"],"mesh_terms":["Adult","Birth Weight","Female","Humans","Infant, Newborn","Infant, Small for Gestational Age","Male","Placenta","Pregnancy","Sex Factors","Case-Control Studies","Fetal Development","PPAR gamma"],"keywords":["Fetus","Receptor","Placenta","Placenta Diseases","Fetal membrane","Peroxisome proliferator","Expression (computer science)","Pregnancy","Gene Expression","Ppar-γ","Small For Gestational Age Birth"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T02:18:03.172635Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}