{"doi":"10.1016/j.ejogrb.2005.02.021","title":"Predictive power of maternal serum and amniotic fluid CRP and PAPP-A concentrations at the time of genetic amniocentesis for the preterm delivery","abstract":null,"journal":"European Journal of Obstetrics &amp; Gynecology and Reproductive Biology","year":2005,"id":618340,"datarank":0.49983067652628066,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.0,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1595084,"name":"Zehra N. Kavak","orcid":null,"position":1,"is_corresponding":false},{"id":1595086,"name":"Hüsnü Gökaslan","orcid":null,"position":2,"is_corresponding":false},{"id":162840,"name":"Koray Elter","orcid":null,"position":3,"is_corresponding":false},{"id":1595088,"name":"Tanju Pekin","orcid":null,"position":4,"is_corresponding":false},{"id":1595082,"name":"Kamer T. Ozer","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Predictive power of maternal serum and amniotic fluid CRP and PAPP-A concentrations at the time of genetic amniocentesis for the preterm delivery","abstract":"<h4>Objective</h4>To investigate whether maternal serum and amniotic fluid CRP and PAPP-A concentrations at the time of genetic amniocentesis are markers of preterm delivery.<h4>Study design</h4>One hundred and forty-one pregnant women were included in this prospective study. Amniotic fluid and maternal serum CRP and PAPP-A concentrations were determined by using commercially available kits. Receiver-operating characteristic (ROC) analysis was performed to determine the efficacy of maternal serum and amniotic fluid CRP and PAPP-A levels in predicting women with preterm delivery.<h4>Results</h4>The prevalence of spontaneous preterm delivery before 37 weeks of gestation was 9.9%. ROC analysis revealed that amniotic fluid CRP level was the only parameter, which had a significant power in the prediction of preterm delivery. The optimum cut-off level was 0.65 mg/L. The sensitivity and specificity were 92.9% and 78.7%, respectively.<h4>Conclusion</h4>The amniotic fluid CRP level has a high sensitivity and specificity in the prediction of preterm delivery and this may be helpful in predicting preterm delivery during genetic amniocentesis.","is_dataset_classified":null,"base_score":3.332204510175204,"endowment":3.332204510175204,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16219520","pmcid":null,"openalex_id":"https://openalex.org/W2103357639","authors":[],"funders":[],"total_grants":0,"fwci":0.7637,"citation_percentile":0.73537569,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":2},{"year":2014,"count":2},{"year":2015,"count":2},{"year":2016,"count":1},{"year":2018,"count":1},{"year":2020,"count":3},{"year":2025,"count":3}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0301211505000825?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0301211505000825?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ejogrb.2005.02.021","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16219520","host_type":"repository"},{"url":"https://hdl.handle.net/11424/228030","host_type":"repository"}],"fields_of_study":["Preterm Birth and Chorioamnionitis","Prenatal Screening and Diagnostics","Pregnancy and preeclampsia studies"],"mesh_terms":["Adult","Amniocentesis","Amniotic Fluid","C-Reactive Protein","Female","Genetic Testing","Humans","Predictive Value of Tests","Pregnancy","Pregnancy-Associated Plasma Protein-A","Risk Factors","ROC Curve","Biomarkers","Premature Birth"],"keywords":["Amniocentesis","Amniotic fluid","Medicine","Preterm delivery","Obstetrics","Receiver operating characteristic","Gestation","Pregnancy","Gynecology","Andrology","Prenatal diagnosis","Internal medicine","Fetus","Biology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T04:07:02.364447Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}