{"doi":"10.1016/j.ejmech.2020.113140","title":"Evaluation of the cellular protection by novel spiropyrazole compounds in dopaminergic cell death","abstract":null,"journal":"European Journal of Medicinal Chemistry","year":2021,"id":603035,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1546818,"name":"Achraf Hibot","orcid":null,"position":1,"is_corresponding":false},{"id":1546819,"name":"Abderrafia Hafid","orcid":null,"position":2,"is_corresponding":false},{"id":1546820,"name":"Mostafa Khouili","orcid":null,"position":3,"is_corresponding":false},{"id":1546821,"name":"Claudia M.B. Neves","orcid":null,"position":4,"is_corresponding":false},{"id":1546822,"name":"Mário M.Q. Simões","orcid":null,"position":5,"is_corresponding":false},{"id":1546823,"name":"M. Graça P.M. S. Neves","orcid":"0000-0002-7953-8166","position":6,"is_corresponding":false},{"id":1546824,"name":"M. Amparo F. Faustino","orcid":null,"position":7,"is_corresponding":false},{"id":1546825,"name":"Taner Dagci","orcid":null,"position":8,"is_corresponding":false},{"id":114938,"name":"Luciano Saso","orcid":null,"position":9,"is_corresponding":false},{"id":1546826,"name":"Güliz Armagan","orcid":null,"position":10,"is_corresponding":false},{"id":1546817,"name":"Jamila Zaiter","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Evaluation of the cellular protection by novel spiropyrazole compounds in dopaminergic cell death","abstract":"The loss of neurons is strongly correlated with aging and aging-associated disorders. In this study, cell viability assays and mitochondrial function were performed to evaluate the effect of new spiro-pyrazole derivatives, prepared from aldehydes and 3-amino-1-phenyl-2-pyrazolin-5-one, on neuroprotection in an in vitro model of dopaminergic cell death induced by 1-methyl-4-phenylpyridinium (MPP<sup>+</sup>). The percentages of neuroprotection by derivatives were found between 21.26% and 52.67% at selected concentrations (10-50 μM) with compound 4d exerting the best neuroprotective effect. The results show that the studied spiropyrazolones perform important roles in dopaminergic neuroprotection and can be used for potential new therapies in the treatment of neurodegenerative disorders including Parkinson's disease.","is_dataset_classified":null,"base_score":2.772588722239781,"endowment":2.772588722239781,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33454549","pmcid":null,"openalex_id":"https://openalex.org/W3119178414","authors":[],"funders":[{"funder_name":"Universidade de Aveiro","grant_id":"","title":null}],"total_grants":1,"fwci":1.1741,"citation_percentile":0.74497379,"influential_citations":0,"citation_trend":[{"year":2021,"count":4},{"year":2022,"count":3},{"year":2023,"count":3},{"year":2024,"count":2},{"year":2025,"count":1},{"year":2026,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0223523420311120?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0223523420311120?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ejmech.2020.113140","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33454549","host_type":"repository"},{"url":"http://hdl.handle.net/11573/1477339","host_type":"repository"}],"fields_of_study":["Synthesis and biological activity","Cholinesterase and Neurodegenerative Diseases","Click Chemistry and Applications","Cell Death","Cell Survival","Cytoprotection","Dopaminergic Neurons","Dose-Response Relationship, Drug","Humans","Molecular Structure","Neuroprotective Agents","Pyrazoles","Spiro Compounds","Structure-Activity Relationship","Tumor Cells, Cultured"],"mesh_terms":["Cell Survival","Dose-Response Relationship, Drug","Humans","Pyrazoles","Spiro Compounds","Structure-Activity Relationship","Tumor Cells, Cultured","Molecular Structure","Cell Death","Neuroprotective Agents","Cytoprotection","Dopaminergic Neurons"],"keywords":["Neuroprotection","Dopaminergic","Chemistry","Programmed cell death","Viability assay","Pharmacology","Parkinson's disease","In vitro","Neuroscience","Biochemistry","Apoptosis","Disease","Dopamine","Internal medicine","Medicine","Biology","Neurodegeneration","Knoevenagel Condensation","Michael Addition","Spiropyrazole"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T20:56:10.573041Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}