{"doi":"10.1016/j.ejmech.2019.03.035","title":"PRODRUGS FOR NITROREDUCTASE BASED CANCER THERAPY- 2: Novel amide/Ntr combinations targeting PC3 cancer cells","abstract":null,"journal":"European Journal of Medicinal Chemistry","year":2019,"id":640928,"datarank":0.49983067652628066,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.0,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":577782,"name":"Ferah Cömert Önder","orcid":"0000-0002-4037-1979","position":1,"is_corresponding":false},{"id":1666053,"name":"Esra Tokay","orcid":null,"position":2,"is_corresponding":false},{"id":1666054,"name":"Ünzile Güven Gülhan","orcid":null,"position":3,"is_corresponding":false},{"id":1666055,"name":"Nelin Hacıoğlu","orcid":null,"position":4,"is_corresponding":false},{"id":728680,"name":"Tuğba Taşkın‐Tok","orcid":"0000-0002-0064-8400","position":5,"is_corresponding":false},{"id":1666056,"name":"Ayhan Çelik","orcid":null,"position":6,"is_corresponding":false},{"id":1666057,"name":"Feray Köçkar","orcid":null,"position":7,"is_corresponding":false},{"id":577786,"name":"Mehmet Ay","orcid":"0000-0002-1095-1614","position":8,"is_corresponding":false},{"id":1666052,"name":"Tuğba Güngör","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"PRODRUGS FOR NITROREDUCTASE BASED CANCER THERAPY- 2: Novel amide/Ntr combinations targeting PC3 cancer cells","abstract":"The use of nitroreductases (NTR) that catalyze the reduction of nitro compounds by using NAD(P)H in GDEPT (Gene-directed enzyme prodrug therapy) studies which minimize toxicity at healthy cells and increases concentration of drugs at cancer cells is remarkable. Discovery of new prodrug/NTR combinations is necessary to be an alternative to known prodrug candidates such as CB1954, SN23862, PR-104A. For this aim, nitro containing aromatic amides (A1-A23)2 were designed, synthesized, performed in silico ADMET and molecular docking techniques in this study. Prodrug candidates were studied on reduction potentials with Ssap-NtrB by HPLC system. Also, cyototoxic properties and prodrug ability of these amides were investigated using different cancer cell lines such as Hep3B and PC3. As a result of theoretical and biological studies, combinations of A5, A6 and A20 with Ssap-NtrB can be suggested as potential prodrugs/enzyme combinations at NTR based cancer therapy compared with CB1954/NfsB.","is_dataset_classified":null,"base_score":3.332204510175204,"endowment":3.332204510175204,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30928710","pmcid":null,"openalex_id":"https://openalex.org/W2926519584","authors":[],"funders":[{"funder_name":"Scientific and Technological Research Council of Turkey-TUBITAK","grant_id":"110T754","title":null},{"funder_name":"Scientific and Technological Research Council of Turkey-TUBITAK","grant_id":"113Z706","title":null}],"total_grants":2,"fwci":1.3257,"citation_percentile":0.80235433,"influential_citations":0,"citation_trend":[{"year":2019,"count":2},{"year":2020,"count":7},{"year":2021,"count":5},{"year":2022,"count":2},{"year":2023,"count":5},{"year":2024,"count":4},{"year":2025,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0223523419302533?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0223523419302533?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ejmech.2019.03.035","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30928710","host_type":"repository"},{"url":"https://avesis.comu.edu.tr/publication/details/6b3b0447-5b20-47c6-ac88-f3195c5454ee/oai","host_type":"repository"}],"fields_of_study":["Advanced biosensing and bioanalysis techniques","Nanomaterials for catalytic reactions","Chemical Reactions and Isotopes","Amides","Antineoplastic Agents, Phytogenic","Cell Line, Tumor","Cell Proliferation","Cell Survival","Chromatography, High Pressure Liquid","Dose-Response Relationship, Drug","Drug Discovery","Drug Screening Assays, Antitumor","Humans","Molecular Dynamics Simulation","Molecular Structure","Nitroreductases","PC-3 Cells","Prodrugs","Structure-Activity Relationship"],"mesh_terms":["PC-3 Cells","Amides","Antineoplastic Agents, Phytogenic","Cell Survival","Chromatography, High Pressure Liquid","Dose-Response Relationship, Drug","Drug Screening Assays, Antitumor","Humans","Nitroreductases","Prodrugs","Structure-Activity Relationship","Molecular Structure","Cell Line, Tumor","Cell Proliferation","Drug Discovery","Molecular Dynamics Simulation"],"keywords":["Prodrug","Nitroreductase","Chemistry","Amide","Adept","Enzyme","Cancer cell","Pharmacology","In silico","Carboxamide","Cancer","Docking (animal)","Combinatorial chemistry","Biochemistry","Medicine","Gene","Internal medicine","Cytotoxicity","Enzymatic activity","Molecular docking","Nitro aromatic amides","Ssap-NtrB"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T14:28:05.331925Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}