{"doi":"10.1016/j.ejmech.2018.10.005","title":"Comparison between porphin, chlorin and bacteriochlorin derivatives for photodynamic therapy: Synthesis, photophysical properties, and biological activity","abstract":null,"journal":"European Journal of Medicinal Chemistry","year":2018,"id":589993,"datarank":1.8372179310888581,"base_score":3.970291913552122,"endowment":3.970291913552122,"self_citation_contribution":0.5955437870328184,"citation_network_contribution":1.2416741440560397,"self_endowment_contribution":0.5955437870328184,"citer_contribution":1.2416741440560397,"corpus_percentile":null,"corpus_rank":null,"citation_count":52,"citer_count":47,"citers_with_citation_signal":44,"citers_with_endowment":44,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1509568,"name":"Ying-Hua Gao","orcid":null,"position":1,"is_corresponding":false},{"id":1509569,"name":"Ping-Yong Liao","orcid":null,"position":2,"is_corresponding":false},{"id":1509570,"name":"Dan-Ye Chen","orcid":null,"position":3,"is_corresponding":false},{"id":1509571,"name":"Ning-Ning Sun","orcid":null,"position":4,"is_corresponding":false},{"id":1509572,"name":"Phuong Anh Nguyen Thi","orcid":null,"position":5,"is_corresponding":false},{"id":1509573,"name":"Yi-Jia Yan","orcid":null,"position":6,"is_corresponding":false},{"id":1509574,"name":"Xiao-Feng Wu","orcid":null,"position":7,"is_corresponding":false},{"id":1509575,"name":"Zhi-Long Chen","orcid":"0000-0001-9716-8368","position":8,"is_corresponding":false},{"id":377061,"name":"Wei Zhu","orcid":"0000-0003-3218-8573","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Comparison between porphin, chlorin and bacteriochlorin derivatives for photodynamic therapy: Synthesis, photophysical properties, and biological activity","abstract":"The development of novel photosensitizers is a challenging task for photodynamic therapy (PDT). Twelve novel photosensitizers (PSs), including porphins (P1-4), chlorins (C1-4) and bacteriochlorins (B1-4) were synthesized. The bacteriochlorins exhibited the longest absorption wavelength (λ<sub>max</sub> = 736 nm), which is higher than that of porphins (λ<sub>max</sub> = 630 nm) and chlorins (λ<sub>max</sub> = 644 nm). In vitro photodynamic activities on Eca-109 human esophageal carcinoma cells were evaluated by standard assays and all PSs showed photodynamic activity. Among them, B2 displayed the highest phototoxicity and the lowest dark toxicity. In addition, B2 exhibited best photodynamic antitumor efficacy on BALB/c nude mice bearing Eca-109 cells tumor. Therefore, B2 is a powerful and promising antitumor photosensitizer for PDT.","is_dataset_classified":null,"base_score":3.970291913552122,"endowment":3.970291913552122,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30336449","pmcid":null,"openalex_id":"https://openalex.org/W2897569540","authors":[],"funders":[{"funder_name":"Central Universities","grant_id":"17D110513","title":null},{"funder_name":"Foundation of Shanghai Science and Technology Committee","grant_id":"15431904100","title":null},{"funder_name":"Foundation of Shanghai Science and Technology Committee","grant_id":"16ZR1400600","title":null},{"funder_name":"Foundation of Shanghai Science and Technology Committee","grant_id":"17PJ1432800","title":null},{"funder_name":"Foundation of Shanghai Science and Technology Committee","grant_id":"17431902600","title":null},{"funder_name":"Foundation of Shanghai Science and Technology Committee","grant_id":"17430741800","title":null},{"funder_name":"Foundation of Shanghai Science and Technology Committee","grant_id":"17430711900","title":null},{"funder_name":"Foundation of Shanghai Science and Technology Committee","grant_id":"18430713000","title":null},{"funder_name":"Ningbo Science and Technology Bureau","grant_id":"2017BS1CA01008","title":null}],"total_grants":9,"fwci":2.7143,"citation_percentile":0.91207238,"influential_citations":0,"citation_trend":[{"year":2019,"count":6},{"year":2020,"count":4},{"year":2021,"count":7},{"year":2022,"count":9},{"year":2023,"count":9},{"year":2024,"count":5},{"year":2025,"count":9},{"year":2026,"count":3}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0223523418308675?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0223523418308675?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ejmech.2018.10.005","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30336449","host_type":"repository"}],"fields_of_study":["Photodynamic Therapy Research Studies","Nanoplatforms for cancer theranostics","Porphyrin and Phthalocyanine Chemistry","Animals","Cell Survival","Dose-Response Relationship, Drug","Esophageal Neoplasms","Female","Humans","Mice","Mice, Inbred BALB C","Mice, Nude","Molecular Structure","Neoplasms, Experimental","Photochemotherapy","Photosensitizing Agents","Porphyrins","Structure-Activity Relationship","Tumor Cells, Cultured"],"mesh_terms":["Animals","Cell Survival","Dose-Response Relationship, Drug","Esophageal Neoplasms","Female","Humans","Mice, Inbred BALB C","Mice, Nude","Neoplasms, Experimental","Photochemotherapy","Porphyrins","Structure-Activity Relationship","Tumor Cells, Cultured","Molecular Structure","Photosensitizing Agents","Mice"],"keywords":["Photodynamic therapy","Phototoxicity","Photosensitizer","Chlorin","Chemistry","In vitro","Fluorescence","Cancer research","Photochemistry","Porphin","Porphyrin","Biochemistry","Medicine","Organic chemistry","Antitumor","Bacteriochlorin"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-24T12:02:45.826857Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}