{"doi":"10.1016/j.ejca.2005.07.024","title":"Pre- and post-chemotherapy alkaline phosphatase levels as prognostic indicators in adults with localised osteosarcoma","abstract":null,"journal":"European Journal of Cancer","year":2005,"id":686236,"datarank":0.5897738449086489,"base_score":3.9318256327243257,"endowment":3.9318256327243257,"self_citation_contribution":0.5897738449086489,"citation_network_contribution":0.0,"self_endowment_contribution":0.5897738449086489,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":50,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1792854,"name":"Adesegun A. Abudu","orcid":null,"position":1,"is_corresponding":false},{"id":1792856,"name":"Roger M. Tillman","orcid":null,"position":2,"is_corresponding":false},{"id":1792858,"name":"Simon R. Carter","orcid":null,"position":3,"is_corresponding":false},{"id":1784669,"name":"Vaiyapuri P. Sumathi","orcid":null,"position":4,"is_corresponding":false},{"id":66012,"name":"Robert J. Grimer","orcid":null,"position":5,"is_corresponding":false},{"id":66015,"name":"Jos A.M. Bramer","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Pre- and post-chemotherapy alkaline phosphatase levels as prognostic indicators in adults with localised osteosarcoma","abstract":"The prognostic value of alkaline phosphatase (AP) measured before and after chemotherapy, but before surgery was established in a retrospective survey of patients. The patients were 18 years or older, with non-metastatic high-grade osteosarcoma. Pre-chemotherapy AP was available in 89 cases, post-chemotherapy AP in 86 patients, and both in 71 cases. AP was classified as Normal (< 100% upper limit), High (100% < or = AP < 200%) or Very High (AP > or = 200%). Osteosarcoma subtype was predominantly conventional. No correlation was found between subtype and chemotherapy response, local recurrence or survival. Pre-chemotherapy AP was raised more in the osteoblastic subtype. Post-chemotherapy AP and normalisation were the same among different subtypes. AP was not correlated with local recurrence. Normal or High pre-chemotherapy AP correlated with better survival at 10 years (64% and 70%) than Very High pre-chemotherapy AP (37%, P = 0.005). Post-chemotherapy AP correlated with survival (68%, 39% and 25% in the Normal, High and Very High group, P = 0.0007) and response to chemotherapy (P = 0.049). A pre-chemotherapy AP above twice Normal correlated with worse survival. If AP decreased after chemotherapy, but was still raised, survival was better, but still worse than if AP normalised. A raised post-chemotherapy AP predicts poor chemotherapy response.","is_dataset_classified":null,"base_score":3.9318256327243257,"endowment":3.9318256327243257,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16274987","pmcid":null,"openalex_id":"https://openalex.org/W2115543187","authors":[],"funders":[],"total_grants":0,"fwci":1.3178,"citation_percentile":0.82088416,"influential_citations":0,"citation_trend":[{"year":2012,"count":5},{"year":2013,"count":3},{"year":2014,"count":4},{"year":2015,"count":5},{"year":2016,"count":4},{"year":2017,"count":1},{"year":2018,"count":3},{"year":2019,"count":4},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0959804905008051?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0959804905008051?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ejca.2005.07.024","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16274987","host_type":"repository"},{"url":"https://pure.amsterdamumc.nl/en/publications/5922570d-59d6-4631-a51e-47e7e73d0357","host_type":"repository"},{"url":"https://pure.amc.nl/en/publications/pre-and-postchemotherapy-alkaline-phosphatase-levels-as-prognostic-indicators-in-adults-with-localised-osteosarcoma(62ffc096-b14c-4540-abca-31aa20f456aa).html","host_type":"repository"}],"fields_of_study":["Sarcoma Diagnosis and Treatment","Bone Tumor Diagnosis and Treatments","Knee injuries and reconstruction techniques"],"mesh_terms":["Adult","Alkaline Phosphatase","Analysis of Variance","Antineoplastic Agents","Bone Neoplasms","Female","Humans","Male","Middle Aged","Prognosis","Retrospective Studies","Osteosarcoma","Biomarkers, Tumor","Survival Analysis"],"keywords":["Osteosarcoma","Alkaline phosphatase","Chemotherapy","Oncology","Medicine","Internal medicine","Cancer research","Chemistry","Enzyme","Biochemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T18:55:19.987567Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}