{"doi":"10.1016/j.ecoenv.2025.119333","title":"Low-dose ionizing radiation promotes lifespan extension and stress resistance of C. elegans via DAF-16/SKN-1 mediated adaptive response","abstract":null,"journal":"Ecotoxicology and Environmental Safety","year":2025,"id":654170,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":520773,"name":"Lei Zhao","orcid":"0000-0002-2367-1355","position":1,"is_corresponding":false},{"id":1549558,"name":"Zejun Li","orcid":"0009-0000-5052-2171","position":2,"is_corresponding":false},{"id":1673721,"name":"Yuhan Dong","orcid":null,"position":3,"is_corresponding":false},{"id":1707257,"name":"Zaishuang Ju","orcid":null,"position":4,"is_corresponding":false},{"id":1707258,"name":"Yeqing Sun","orcid":null,"position":5,"is_corresponding":false},{"id":1202481,"name":"Ge Zhang","orcid":"0009-0008-6483-3833","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Low-dose ionizing radiation promotes lifespan extension and stress resistance of C. elegans via DAF-16/SKN-1 mediated adaptive response","abstract":"Exposure to ionizing radiation (IR) has raised significant concern regarding potential health risks, particularly the frailty-like syndromes. Paradoxically, emerging evidence suggests that low-dose IR exposure may exert opposite effects. In this study, we show that exposure to 0.5 and 2.0 Gy X-rays extends lifespan in C. elegans . We demonstrate that elevated levels of persistent reactive oxygen species (ROS) and mitochondrial ROS induced by low-dose IR act as key drivers in activating the transcription factors (TFs) DAF-16 and SKN-1 in C. elegans . Additionally, we elucidate that under low-dose IR exposure, DAF-16 regulates the expression of skn-1 , while SKN-1 binds to the promoters of antioxidant genes through a conserved motif, thereby initiating adaptive responses that maintain redox homeostasis, enhance stress resistance, and ultimately promote lifespan extension. This work identifies a critical regulatory network that drives lifespan extension and stress resistance in C. elegans , and provides candidate targets and mechanistic insights for preventive interventions aimed at mitigating IR-induced aging and lifespan shortening. • Low-dose IR exposure extends lifespan and boosts stress resistance in C. elegans . • Low-dose IR induces evaluated ROS and mtROS levels, and triggers mt UPR. • DAF-16 and SKN-1 links ROS signaling to redox homeostasis and stress resistance. • DAF-16–SKN-1–antioxidant network drives low-dose IR-induced lifespan extension. • Key targets identified for preventing IR-induced lifespan reduction.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41187536","pmcid":null,"openalex_id":"https://openalex.org/W4415828661","authors":[],"funders":[{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"3132023528","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"32071244","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"","title":null}],"total_grants":3,"fwci":0.4867,"citation_percentile":0.64961759,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.ecoenv.2025.119333","host_type":"journal"},{"url":"https://doi.org/10.1016/j.ecoenv.2025.119333","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0147651325016781?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0147651325016781?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41187536","host_type":"repository"},{"url":"https://doaj.org/article/2cdbd3bdd34c48b786d8c65e3b0710bc","host_type":"repository"}],"fields_of_study":["Genetics, Aging, and Longevity in Model Organisms","Tardigrade Biology and Ecology","DNA Repair Mechanisms"],"mesh_terms":["Adaptation, Physiological","Animals","DNA-Binding Proteins","Longevity","Radiation, Ionizing","Stress, Physiological","Transcription Factors","Caenorhabditis elegans","Reactive Oxygen Species","Caenorhabditis elegans Proteins","Forkhead Transcription Factors"],"keywords":["Reactive oxygen species","Oxidative stress","Ionizing radiation","Transcription factor","Adaptive response","Caenorhabditis elegans","Hormesis","Longevity","Cellular stress response","Transcription (linguistics)","stress resistance","Mitochondrial Stress","Lifespan Extension","Antioxidant Pathway"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T04:23:03.138922Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}