{"doi":"10.1016/j.eclinm.2025.103221","title":"The relationship between obesity and obstructive sleep apnea in four community-based cohorts: an individual participant data meta-analysis of 12,860 adults","abstract":"Background: Obesity is a well-established risk factor for obstructive sleep apnea (OSA). We assessed the reciprocal prevalence of obesity and OSA and how it varies by age and sex. Methods: Following a systematic review through March 27, 2025, the final sample included four community-based cohort studies in the US and Switzerland. OSA severity was quantified using the apnea-hypopnea index (AHI, all apneas plus hypopneas with ≥4% oxygen desaturation/hour). Random effects individual participant data (IPD) meta-analyses estimated prevalences. Logistic regression compared odds of OSA across weight groups. Findings: were 2.18 [1.73-2.76] and 4.84 [3.09-6.00], respectively. Interpretation: Our analyses show that most adults with OSA do not have obesity, with 44.4% having overweight and 23.5% having normal weight or underweight. Obesity was more prevalent among females compared to males and in younger individuals (<65 years) compared to older individuals with OSA. Recognizing OSA is not exclusive to obesity highlights the need for personalized treatment plans. Funding: American Academy of Sleep Medicine, National Heart, Lung, and Blood Institute, and Apnimed.","journal":"EClinicalMedicine","year":2025,"id":509138,"datarank":0.7877985271689654,"base_score":3.828641396489095,"endowment":3.828641396489095,"self_citation_contribution":0.5742962094733643,"citation_network_contribution":0.213502317695601,"self_endowment_contribution":0.5742962094733643,"citer_contribution":0.213502317695601,"corpus_percentile":74.44109228746035,"corpus_rank":3305,"citation_count":45,"citer_count":45,"citers_with_citation_signal":14,"citers_with_endowment":14,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.6212,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":851217,"name":"L. Gell","orcid":"0000-0001-7363-7887","position":1,"is_corresponding":false},{"id":1361926,"name":"Théo Imler","orcid":"0009-0000-7105-1161","position":2,"is_corresponding":false},{"id":1029750,"name":"Mohammadreza Hajipour","orcid":"0000-0003-1653-1837","position":3,"is_corresponding":false},{"id":245148,"name":"Luigi Taranto‐Montemurro","orcid":"0000-0001-7080-0335","position":4,"is_corresponding":false},{"id":267369,"name":"Ludovico Messineo","orcid":"0000-0002-4142-9124","position":5,"is_corresponding":false},{"id":245151,"name":"Katie L. Stone","orcid":"0000-0003-2797-3171","position":6,"is_corresponding":false},{"id":245147,"name":"Scott A. Sands","orcid":"0000-0003-3752-0328","position":7,"is_corresponding":false},{"id":616313,"name":"Najib Ayas","orcid":"0000-0003-2742-6514","position":8,"is_corresponding":false},{"id":224947,"name":"John Yee","orcid":null,"position":9,"is_corresponding":false},{"id":1362937,"name":"John Cronin","orcid":null,"position":10,"is_corresponding":false},{"id":880541,"name":"Raphaël Heinzer","orcid":"0000-0002-3215-7788","position":11,"is_corresponding":false},{"id":245152,"name":"Andrew Wellman","orcid":"0000-0002-9000-3007","position":12,"is_corresponding":false},{"id":17008,"name":"Susan Redline","orcid":"0000-0002-6585-1610","position":13,"is_corresponding":false},{"id":245146,"name":"Ali Azarbarzin","orcid":"0000-0002-4986-4753","position":14,"is_corresponding":false},{"id":1021082,"name":"Neda Esmaeili","orcid":"0009-0008-4956-1497","position":0,"is_corresponding":true}],"reference_count":88,"raw_metadata":null,"created_at":"2026-07-19T02:47:00.188082Z","pmid":"40330547","pmcid":"PMC12051718","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}