{"doi":"10.1016/j.eclinm.2020.100545","title":"Towards characterized convalescent plasma for COVID-19: The dose matters","abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19, remains a global health crisis with limited treatment options. While randomized controlled trials have demonstrated some efficacy of the antiviral agent remdesivir and the corticosteroid dexamethasone in COVID-19 treatment, any beneficial role of convalescent plasma (CP) has been less clear [[1]Beigel J.H. Tomashek K.M. Dodd L.E. et al.Remdesivir for the treatment of Covid-19 — preliminary report.N Engl J Med. 2020; (published online May 22)https://doi.org/10.1056/NEJMoa2007764Crossref PubMed Scopus (4623) Google Scholar,[2]Dexamethasone in hospitalized patients with Covid-19 — preliminary report.N Engl J Med. 2020; 0 (null)Google Scholar]. Since the early 20th century convalescent blood products and their antibody derivatives have been used for the treatment and prevention of infectious diseases. The discovery of potent antibiotics has largely supplanted any role for CP in treating bacterial infections, yet CP remains an important tool in the early stages of outbreaks of emerging or re-emerging viral pathogens for which therapeutic options are limited. A historical meta-analysis by Luke et al. [[3]Luke T.C. Kilbane E.M. Jackson J.L. Hoffman S.L Meta-analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment.Ann Intern Med. 2006; 145: 599-609Crossref PubMed Scopus (487) Google Scholar] on the 1918 H1N1 influenza pandemic found a significant reduction in mortality associated with CP use. This finding is consistent with reductions in both viral load and mortality with CP use among severely ill patients in the more recent 2009 H5N1 swine flu pandemic [[4]Hung I.F. To K.K. Lee C.-.K. et al.Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection.Clin Infect Dis Off Publ Infect Dis Soc Am. 2011; 52: 447-456Crossref PubMed Scopus (534) Google Scholar]. Evidence from other coronavirus outbreaks, including MERS and SARS-CoV-1, as well as the 2014 Ebola virus outbreak, is less conclusive [5Soo Y.O.Y. Cheng Y. Wong R. et al.Retrospective comparison of convalescent plasma with continuing high‐dose methylprednisolone treatment in SARS patients.Clin Microbiol Infect. 2004; 10: 676-678Summary Full Text Full Text PDF PubMed Scopus (309) Google Scholar, 6Park W.B. Perera R.A.P.M. Choe P.G. et al.Kinetics of serologic responses to MERS coronavirus infection in humans, South Korea.Emerg Infect Dis. 2015; 21: 2186-2189Crossref PubMed Scopus (113) Google Scholar, 7Min C.-.K. Cheon S. Ha N.-.Y. et al.Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity.Sci Rep. 2016; 6: 25359Crossref PubMed Scopus (283) Google Scholar], relying on limited patient cohorts and case series. These conflicting results are to be expected given the heterogeneous nature of CP, the common practice of transfusing CP prior to its characterization, and the clinical severity and diversity of recipients qualifying for its empirical use. The total antibody amount, class, subclass, specificity, neutralizing activity, and potential to induce antibody-dependent cell-mediated cytotoxicity are just some of the complex factors that may influence CP-associated outcomes. A broad consensus among physicians and scientists has emerged in the current pandemic that characterization of the antibodies within CP units is essential for determining correlates of efficacy. In recent weeks, a multi-center study including 35,322 patients from 2807 acute care facilities by the US EAP COVID-19 Plasma Consortium reported significant reductions in 7 and 30 day mortality with early use of CP containing high levels of SARS-CoV-2 specific IgG antibodies in a subset of patients [[8]Joyner MJ, Senefeld JW, Klassen SA, et al. Effect of convalescent plasma on mortality among hospitalized patients with COVID-19: initial three-month experi","journal":"EClinicalMedicine","year":2020,"id":74073,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9627,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":388038,"name":"Cheryl L. Maier","orcid":"0000-0003-4044-2674","position":1,"is_corresponding":false},{"id":226159,"name":"Hans Verkerke","orcid":"0000-0002-5152-0095","position":0,"is_corresponding":true}],"reference_count":13,"raw_metadata":null,"created_at":"2026-07-18T21:45:52.171053Z","pmid":"32984783","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}