{"doi":"10.1016/j.echo.2023.12.003","title":"Multiple Phenotypes of Chronic Coronary Syndromes Identified by ABCDE Stress Echocardiography","abstract":null,"journal":"Journal of the American Society of Echocardiography","year":2024,"id":638382,"datarank":0.4566783656585135,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.0,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1658025,"name":"Quirino Ciampi","orcid":null,"position":1,"is_corresponding":false},{"id":1658027,"name":"Lauro Cortigiani","orcid":null,"position":2,"is_corresponding":false},{"id":1658028,"name":"Karina Wierzbowska-Drabik","orcid":null,"position":3,"is_corresponding":false},{"id":1658029,"name":"Angela Zagatina","orcid":null,"position":4,"is_corresponding":false},{"id":1658030,"name":"Ana Djordjevic-Dikic","orcid":null,"position":5,"is_corresponding":false},{"id":899566,"name":"Fiore Manganelli","orcid":"0000-0002-1442-9604","position":6,"is_corresponding":false},{"id":1658031,"name":"Alla Boshchenko","orcid":null,"position":7,"is_corresponding":false},{"id":1658032,"name":"Clarissa Borguezan-Daros","orcid":null,"position":8,"is_corresponding":false},{"id":1658033,"name":"Rosina Arbucci","orcid":null,"position":9,"is_corresponding":false},{"id":1658035,"name":"Sofia Marconi","orcid":null,"position":10,"is_corresponding":false},{"id":1658036,"name":"Jorge Lowenstein","orcid":null,"position":11,"is_corresponding":false},{"id":1056277,"name":"Maciej Haberka","orcid":"0000-0002-2296-8827","position":12,"is_corresponding":false},{"id":1658039,"name":"Jelena Celutkiene","orcid":null,"position":13,"is_corresponding":false},{"id":411461,"name":"Antonello D’Andrea","orcid":"0000-0002-9698-9145","position":14,"is_corresponding":false},{"id":1658042,"name":"Hugo Rodriguez-Zanella","orcid":null,"position":15,"is_corresponding":false},{"id":40688,"name":"Fausto Rigo","orcid":"0000-0002-8488-4469","position":16,"is_corresponding":false},{"id":1658045,"name":"Ines Monte","orcid":null,"position":17,"is_corresponding":false},{"id":1658046,"name":"Marco Fabio Costantino","orcid":null,"position":18,"is_corresponding":false},{"id":1658047,"name":"Miodrag Ostojic","orcid":null,"position":19,"is_corresponding":false},{"id":1658048,"name":"Elisa Merli","orcid":null,"position":20,"is_corresponding":false},{"id":1289041,"name":"Mauro Pepi","orcid":"0000-0003-2524-6288","position":21,"is_corresponding":false},{"id":58213,"name":"Scipione Carerj","orcid":"0000-0002-3471-7996","position":22,"is_corresponding":false},{"id":1658049,"name":"Jaroslaw D. Kasprzak","orcid":null,"position":23,"is_corresponding":false},{"id":63717,"name":"Patricia A. Pellikka","orcid":"0000-0001-6800-3521","position":24,"is_corresponding":false},{"id":1207208,"name":"Eugenio Picano","orcid":"0000-0002-6375-6361","position":25,"is_corresponding":false},{"id":979234,"name":"Nicola Gaibazzi","orcid":"0000-0002-2207-3388","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Multiple Phenotypes of Chronic Coronary Syndromes Identified by ABCDE Stress Echocardiography","abstract":"<h4>Background</h4>Regional wall motion abnormality is considered a sensitive and specific marker of ischemia during stress echocardiography (SE). However, ischemia is a multifaceted entity associated with either coronary artery disease (CAD) or angina with normal coronary arteries, a distinction difficult to make using a single sign. The aim of this study was to evaluate the diagnostic potential of the five-step ABCDE SE protocol for CAD detection.<h4>Methods</h4>From the 2016-2022 Stress Echo 2030 study data bank, 3,229 patients were selected (mean age, 66 ± 12 years; 2,089 men [65%]) with known CAD (n = 1,792) or angina with normal coronary arteries (n = 1,437). All patients were studied using both the ABCDE SE protocol and coronary angiography, within 3 months. In step A, regional wall motion abnormality is assessed; in step B, B-lines and diastolic function; in step C, left ventricular contractile reserve; in step D, coronary flow velocity reserve in the left anterior descending coronary artery; and in step E, heart rate reserve.<h4>Results</h4>SE response ranged from a score of 0 (all steps normal) to a score of 5 (all steps abnormal). For CAD, rates of abnormal results were 347 for step A (19.4%), 547 (30.5%) for step B, 720 (40.2%) for step C, 615 (34.3%) for step D, and 633 (35.3%) for step E. For angina with normal coronary arteries, rates of abnormal results were 81 (5.6%) for step A, 429 (29.9%) for step B, 432 (30.1%) for step C, 354 (24.6%) for step D, and 445 (31.0%) for step E. The dominant \"solitary phenotype\" was step B in 109 patients (9.1%).<h4>Conclusions</h4>Stress-induced ischemia presents with a wide range of diagnostic phenotypes, highlighting its complex nature. Using a comprehensive approach such as the advanced ABCDE score, which combines multiple markers, proves to be more valuable than relying on a single marker in isolation.","is_dataset_classified":null,"base_score":3.044522437723423,"endowment":3.044522437723423,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38092306","pmcid":null,"openalex_id":"https://openalex.org/W4389617166","authors":[],"funders":[],"total_grants":0,"fwci":3.1068,"citation_percentile":0.92482667,"influential_citations":0,"citation_trend":[{"year":2024,"count":6},{"year":2025,"count":8},{"year":2026,"count":6}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0894731723006521?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0894731723006521?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.echo.2023.12.003","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38092306","host_type":"repository"}],"fields_of_study":["Cardiac Imaging and Diagnostics","Takotsubo Cardiomyopathy and Associated Phenomena","Coronary Interventions and Diagnostics"],"mesh_terms":["Aged","Chronic Disease","Coronary Artery Disease","Coronary Vessels","Female","Humans","Male","Middle Aged","Phenotype","Coronary Angiography","Echocardiography, Stress"],"keywords":["Medicine","Cardiology","Internal medicine","Coronary artery disease","Stress Echocardiography","Fractional flow reserve","Ischemia","Angina","Diastole","Coronary angiography","Blood pressure","Myocardial infarction","Stress","Myocardial ischemia","Echocardiography","Ischemic Cascade"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T20:35:41.256867Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}