{"doi":"10.1016/j.ebr.2022.100570","title":"Multimodal approach leads to seizure-freedom in a case of highly refractory drug-resistant focal epilepsy","abstract":"Drug-resistant, nonlesional, extratemporal lobe focal epilepsy can be difficult to treat and may require a high degree of multidisciplinary teamwork to localize the seizure onset zone for resective surgery. Here, we describe a patient with longstanding drug-resistant, nonlesional, extratemporal focal epilepsy with a high seizure burden who became seizure-free after prolonged evaluation and eventual left frontal cortical resection. Prior evaluations included magnetoencephalography, invasive video-EEG monitoring, and implantation of a responsive neurostimulation (RNS) device for ongoing intracranial stimulation. Highly sophisticated techniques were utilized including stereotactic localization of prior evaluations to guide repeat stereo-EEG (SEEG), electrical stimulation mapping, SEEG-guided radiofrequency ablation, and awake resection with language and motor mapping using a cognitive testing platform . Incorporating a wide array of data from multiple centers and evaluation time periods was necessary to optimize seizure control and minimize the risk of neurological deficits from surgery.","journal":"Epilepsy & Behavior Reports","year":2022,"id":292188,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9469,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":976361,"name":"Eva C. Alden","orcid":null,"position":1,"is_corresponding":false},{"id":975871,"name":"Hugh D. Simpson","orcid":"0000-0001-8695-1904","position":2,"is_corresponding":false},{"id":271428,"name":"Benjamin H. Brinkmann","orcid":"0000-0002-2392-8608","position":3,"is_corresponding":false},{"id":285708,"name":"Nicholas M. Gregg","orcid":"0000-0002-6151-043X","position":4,"is_corresponding":false},{"id":270408,"name":"Kai J. Miller","orcid":"0000-0002-6687-6422","position":5,"is_corresponding":false},{"id":227180,"name":"Brian N. Lundstrom","orcid":"0000-0002-5310-5549","position":6,"is_corresponding":false},{"id":314368,"name":"Kelsey Smith","orcid":"0000-0003-4536-082X","position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:30:42.221508Z","pmid":"36411878","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}