{"doi":"10.1016/j.ebiom.2024.105243","title":"Near-infrared II fluorescence-guided glioblastoma surgery targeting monocarboxylate transporter 4 combined with photothermal therapy","abstract":null,"journal":"eBioMedicine","year":2024,"id":641869,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1669153,"name":"Chunzhao Li","orcid":null,"position":1,"is_corresponding":false},{"id":500679,"name":"Xiaojing Shi","orcid":"0000-0002-7258-0636","position":2,"is_corresponding":false},{"id":1669155,"name":"Jinnan Zhang","orcid":null,"position":3,"is_corresponding":false},{"id":1669156,"name":"Xiaohua Jia","orcid":null,"position":4,"is_corresponding":false},{"id":362237,"name":"Zhenhua Hu","orcid":"0000-0001-5336-7103","position":5,"is_corresponding":false},{"id":1669159,"name":"Yufei Gao","orcid":null,"position":6,"is_corresponding":false},{"id":312083,"name":"Jie Tian","orcid":"0000-0003-0498-0432","position":7,"is_corresponding":false},{"id":921053,"name":"Hongyang Zhao","orcid":"0000-0003-4711-0314","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Near-infrared II fluorescence-guided glioblastoma surgery targeting monocarboxylate transporter 4 combined with photothermal therapy","abstract":"BACKGROUND: Surgery is crucial for glioma treatment, but achieving complete tumour removal remains challenging. We evaluated the effectiveness of a probe targeting monocarboxylate transporter 4 (MCT4) in recognising gliomas, and of near-infrared window II (NIR-II) fluorescent molecular imaging and photothermal therapy as treatment strategies. METHODS: We combined an MCT4-specific monoclonal antibody with indocyanine green to create the probe. An orthotopic mouse model and a transwell model were used to evaluate its ability to guide tumour resection using NIR-II fluorescence and to penetrate the blood-brain barrier (BBB), respectively. A subcutaneous tumour model was established to confirm photothermal therapy efficacy. Probe specificity was assessed in brain tissue from mice and humans. Finally, probe effectiveness in photothermal therapy was investigated. FINDINGS: MCT4 was differentially expressed in tumour and normal brain tissue. The designed probe exhibited precise tumour targeting. Tumour imaging was precise, with a signal-to-background (SBR) ratio of 2.8. Residual tumour cells were absent from brain tissue postoperatively (SBR: 6.3). The probe exhibited robust penetration of the BBB. Moreover, the probe increased the tumour temperature to 50 °C within 5 min of laser excitation. Photothermal therapy significantly reduced tumour volume and extended survival time in mice without damage to vital organs. INTERPRETATION: These findings highlight the potential efficacy of our probe for fluorescence-guided surgery and therapeutic interventions. FUNDING: Jilin Province Department of Science and Technology (20200403079SF), Department of Finance (2021SCZ06) and Development and Reform Commission (20200601002JC); National Natural Science Foundation of China (92059207, 92359301, 62027901, 81930053, 81227901, U21A20386); and CAS Youth Interdisciplinary Team (JCTD-2021-08).","is_dataset_classified":null,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39004066","pmcid":"PMC11284385","openalex_id":"https://openalex.org/W4400605481","authors":[],"funders":[{"funder_name":"Department of Science and Technology of Jilin Province","grant_id":"20200403079SF","title":null},{"funder_name":"Chinese Academy of Sciences","grant_id":"JCTD-2021-08","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"92059207","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"92359301","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"62027901","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81227901","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"U21A20386","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81930053","title":null},{"funder_name":"Jilin Province Development and Reform Commission","grant_id":"20200601002JC","title":null},{"funder_name":"Department of Finance of Jilin Province","grant_id":"2020SCZ09","title":null},{"funder_name":"Department of Finance","grant_id":"2021SCZ06","title":null},{"funder_name":"Anhui Provincial Development and Reform Commission","grant_id":"","title":null}],"total_grants":12,"fwci":2.1139,"citation_percentile":0.87077211,"influential_citations":0,"citation_trend":[{"year":2024,"count":3},{"year":2025,"count":6},{"year":2026,"count":8}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.ebiom.2024.105243","host_type":"journal"},{"url":"https://doi.org/10.1016/j.ebiom.2024.105243","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2352396424002792?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2352396424002792?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39004066","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11284385","host_type":"repository"},{"url":"https://doaj.org/article/3f2953dbe1614097a2828969b198ee1b","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11284385/pdf/main.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11284385","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11284385?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Nanoplatforms for cancer theranostics","Photodynamic Therapy Research Studies","Cancer, Hypoxia, and Metabolism","Animals","Mice","Monocarboxylic Acid Transporters","Humans","Photothermal Therapy","Glioblastoma","Cell Line, Tumor","Brain Neoplasms","Surgery, Computer-Assisted","Disease Models, Animal","Blood-Brain Barrier","Muscle Proteins","Optical Imaging","Xenograft Model Antitumor Assays"],"mesh_terms":["Photothermal Therapy","Animals","Blood-Brain Barrier","Brain Neoplasms","Disease Models, Animal","Glioblastoma","Humans","Muscle Proteins","Xenograft Model Antitumor Assays","Surgery, Computer-Assisted","Monocarboxylic Acid Transporters","Cell Line, Tumor","Mice","Optical Imaging"],"keywords":["Glioblastoma","Photothermal therapy","Cancer research","Transporter","Medicine","Fluorescence","Chemistry","Materials science","Nanotechnology","Biochemistry","Optics","Gene","Glioma","Monocarboxylate Transporter 4","Near-infrared Window Ii","Fluorescent Molecular Imaging"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"cellosaurus"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T20:46:18.074998Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}