{"doi":"10.1016/j.ebiom.2024.105241","title":"Dysglycaemia in Ebola virus disease: a retrospective analysis from the 2018 to 2020 outbreak","abstract":"BACKGROUND: Ebola virus disease (EVD) is associated with multisystem organ failure and high mortality. Severe hypoglycaemia is common, life-threatening, and correctable in critically ill patients, but glucose monitoring may be limited in EVD treatment units. METHODS: We conducted a retrospective review of patients admitted to EVD treatment units in Butembo and Katwa, Eastern DRC. Glucose measurements were done using a handheld glucometer at the bedside or using the Piccolo xpress Chemistry Analyzer on venous samples. FINDINGS: 384 patients (median age 30 years (interquartile range, IQR, 20-45), 57% female) and 6422 glucose measurements (median 11 per patient, IQR 4-22) were included in the analysis. Severe hypoglycaemia (≤2.2 mmol/L) and hyperglycaemia (>10 mmol/L) were recorded at least once during the ETU admission in 97 (25%) and 225 (59%) patients, respectively. A total of 2004 infusions of glucose-containing intravenous solutions were administered to 302 patients (79%) with a median cumulative dose of 175g (IQR 100-411). The overall case fatality rate was 157/384 (41%) and was 2.2-fold higher (95% CI 1.3-3.8) in patients with severe hypoglycaemia than those without hypoglycaemia (p = 0.0042). In a multivariable Cox proportional hazards model, periods of severe hypoglycaemia (adjusted hazard ratio (aHR) 6.2, 95% CI 3.2-12, p < 0.0001) and moderate hypoglycaemia (aHR 3.0, 95% CI 1.9-4.8, p < 0.0001) were associated with elevated mortality. INTERPRETATION: Hypoglycaemia is common in EVD, requires repeated correction with intravenous dextrose solutions, and is associated with mortality. FUNDING: This study was not supported by any specific funding.","journal":"EBioMedicine","year":2024,"id":480620,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9387,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":564680,"name":"Daniel Mukadi‐Bamuleka","orcid":"0000-0002-6836-8704","position":1,"is_corresponding":false},{"id":1320474,"name":"Kitenge-Omasumbu Richard","orcid":null,"position":2,"is_corresponding":false},{"id":1320475,"name":"Katsuva Mbahweka Francois","orcid":null,"position":3,"is_corresponding":false},{"id":1320476,"name":"Paluku Mwalitsa Jean Paul","orcid":null,"position":4,"is_corresponding":false},{"id":1320477,"name":"Kavugho Muliwavyo","orcid":null,"position":5,"is_corresponding":false},{"id":332883,"name":"François Edidi-Atani","orcid":null,"position":6,"is_corresponding":false},{"id":973309,"name":"Meris Matondo Kuamfumu","orcid":null,"position":7,"is_corresponding":false},{"id":636176,"name":"Sabue Mulangu","orcid":"0000-0002-2722-2637","position":8,"is_corresponding":false},{"id":973310,"name":"Olivier Tshiani-Mbaya","orcid":null,"position":9,"is_corresponding":false},{"id":246875,"name":"Placide Mbala‐Kingebeni","orcid":"0000-0003-1556-3570","position":10,"is_corresponding":false},{"id":246876,"name":"Steve Ahuka‐Mundeke","orcid":"0009-0009-5210-864X","position":11,"is_corresponding":false},{"id":896846,"name":"Jean-Jacques Muyembe-Tamfum","orcid":null,"position":12,"is_corresponding":false},{"id":729995,"name":"Bonita E. Lee","orcid":"0000-0001-8510-237X","position":13,"is_corresponding":false},{"id":1274007,"name":"Stan Houston","orcid":"0000-0003-4544-4425","position":14,"is_corresponding":false},{"id":1274008,"name":"Zubia Mumtaz","orcid":"0000-0003-4590-9739","position":15,"is_corresponding":false},{"id":972777,"name":"Michael Hawkes","orcid":"0000-0002-4122-0937","position":16,"is_corresponding":false},{"id":973307,"name":"Kasereka Masumbuko Claude","orcid":null,"position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:07:02.142014Z","pmid":"38981161","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}