{"doi":"10.1016/j.ebiom.2023.104623","title":"Evaluation of pre-diagnostic blood protein measurements for predicting survival after lung cancer diagnosis","abstract":"BACKGROUND: To evaluate whether circulating proteins are associated with survival after lung cancer diagnosis, and whether they can improve prediction of prognosis. METHODS: We measured up to 1159 proteins in blood samples from 708 participants in 6 cohorts. Samples were collected within 3 years prior to lung cancer diagnosis. We used Cox proportional hazards models to identify proteins associated with overall mortality after lung cancer diagnosis. To evaluate model performance, we used a round-robin approach in which models were fit in 5 cohorts and evaluated in the 6th cohort. Specifically, we fit a model including 5 proteins and clinical parameters and compared its performance with clinical parameters only. FINDINGS: There were 86 proteins nominally associated with mortality (p < 0.05), but only CDCP1 remained statistically significant after accounting for multiple testing (hazard ratio per standard deviation: 1.19, 95% CI: 1.10-1.30, unadjusted p = 0.00004). The external C-index for the protein-based model was 0.63 (95% CI: 0.61-0.66), compared with 0.62 (95% CI: 0.59-0.64) for the model with clinical parameters only. Inclusion of proteins did not provide a statistically significant improvement in discrimination (C-index difference: 0.015, 95% CI: -0.003 to 0.035). INTERPRETATION: Blood proteins measured within 3 years prior to lung cancer diagnosis were not strongly associated with lung cancer survival, nor did they importantly improve prediction of prognosis beyond clinical information. FUNDING: No explicit funding for this study. Authors and data collection supported by the US National Cancer Institute (U19CA203654), INCA (France, 2019-1-TABAC-01), Cancer Research Foundation of Northern Sweden (AMP19-962), and Swedish Department of Health Ministry.","journal":"EBioMedicine","year":2023,"id":368591,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9523,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":353906,"name":"David C. Muller","orcid":"0000-0002-2350-0417","position":1,"is_corresponding":false},{"id":816349,"name":"Hana Zahed","orcid":"0000-0002-5731-8859","position":2,"is_corresponding":false},{"id":651209,"name":"Karine Alcala","orcid":"0000-0003-2308-9880","position":3,"is_corresponding":false},{"id":816348,"name":"Florence Guida","orcid":"0000-0002-9652-2430","position":4,"is_corresponding":false},{"id":246453,"name":"Karl Smith-Byrne","orcid":"0000-0002-1932-7463","position":5,"is_corresponding":false},{"id":301084,"name":"Jian‐Min Yuan","orcid":"0000-0002-7664-7084","position":6,"is_corresponding":false},{"id":260003,"name":"Woon‐Puay Koh","orcid":"0000-0002-5674-6341","position":7,"is_corresponding":false},{"id":388290,"name":"Renwei Wang","orcid":"0000-0001-8871-7054","position":8,"is_corresponding":false},{"id":34653,"name":"Roger L. Milne","orcid":"0000-0001-5764-7268","position":9,"is_corresponding":false},{"id":305421,"name":"Julie K. Bassett","orcid":"0000-0003-0799-4821","position":10,"is_corresponding":false},{"id":347014,"name":"Arnulf Langhammer","orcid":"0000-0001-5296-6673","position":11,"is_corresponding":false},{"id":262547,"name":"Kristian Hveem","orcid":"0000-0001-8157-9744","position":12,"is_corresponding":false},{"id":291309,"name":"Victoria L. Stevens","orcid":"0000-0003-0259-4407","position":13,"is_corresponding":false},{"id":1022750,"name":"Ying Wang","orcid":"0000-0002-9724-6060","position":14,"is_corresponding":false},{"id":251844,"name":"Mikael Johansson","orcid":"0000-0003-4182-8923","position":15,"is_corresponding":false},{"id":39584,"name":"Anne Tjønneland","orcid":"0000-0003-4385-2097","position":16,"is_corresponding":false},{"id":353907,"name":"­Rosario ­Tumino","orcid":"0000-0003-2666-414X","position":17,"is_corresponding":false},{"id":275783,"name":"Mahdi Sheikh","orcid":"0000-0003-3972-7824","position":18,"is_corresponding":false},{"id":38786,"name":"Mattias Johansson","orcid":"0000-0002-3116-5081","position":19,"is_corresponding":false},{"id":630694,"name":"Hilary A. 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