{"doi":"10.1016/j.ebiom.2022.104124","title":"Intermittent calorie restriction alters T cell subsets and metabolic markers in people with multiple sclerosis","abstract":"BACKGROUND: Intermittent fasting or calorie restriction (CR) diets provide anti-inflammatory and neuroprotective advantages in models of multiple sclerosis (MS); data in humans are sparse. METHODS: ) T cell subsets including effector memory, central memory, and naïve cells. FINDINGS: : 10.11%; 95%CI: 3.30, 16.92%). No changes were observed for daily CR or weight-stable diets. Larger within-person changes in lysophospholipid and lysoplasmalogen metabolites in intermittent CR were associated with larger reductions in memory T cell subsets and larger increases in naïve T cell subsets. INTERPRETATION: In people with MS, an intermittent CR diet was associated with reduction in memory T cell subsets and certain biologically-relevant lipid markers. FUNDING: National MS Society, NIH, Johns Hopkins Catalyst Award.","journal":"EBioMedicine","year":2022,"id":236743,"datarank":0.6307038929086449,"base_score":4.204692619390966,"endowment":4.204692619390966,"self_citation_contribution":0.6307038929086449,"citation_network_contribution":0.0,"self_endowment_contribution":0.6307038929086449,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":66,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8458,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":241629,"name":"Pavan Bhargava","orcid":"0000-0002-7947-9418","position":1,"is_corresponding":false},{"id":241630,"name":"Matthew D. Smith","orcid":"0000-0001-6614-569X","position":2,"is_corresponding":false},{"id":465914,"name":"Diane Vizthum","orcid":"0000-0002-1633-1600","position":3,"is_corresponding":false},{"id":375743,"name":"Bobbie J. Henry-Barron","orcid":"0000-0001-5390-794X","position":4,"is_corresponding":false},{"id":337172,"name":"Michael D. Kornberg","orcid":"0000-0003-2588-7325","position":5,"is_corresponding":false},{"id":857754,"name":"Sandra D. Cassard","orcid":"0000-0001-6677-1877","position":6,"is_corresponding":false},{"id":256661,"name":"Dimitrios Kapogiannis","orcid":"0000-0003-2181-3118","position":7,"is_corresponding":false},{"id":254907,"name":"Patrick S. Sullivan","orcid":"0000-0002-7728-0587","position":8,"is_corresponding":false},{"id":274355,"name":"David J. Baer","orcid":"0000-0003-3454-2097","position":9,"is_corresponding":false},{"id":241645,"name":"Peter A. Calabresi","orcid":"0000-0002-7776-6472","position":10,"is_corresponding":false},{"id":241643,"name":"Ellen M. Mowry","orcid":"0000-0003-0623-5188","position":11,"is_corresponding":false},{"id":241632,"name":"Kathryn C. Fitzgerald","orcid":"0000-0003-3137-0322","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:22:03.686498Z","pmid":"35816900","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}