{"doi":"10.1016/j.ebiom.2020.102864","title":"Autophagy in preeclampsia: A new target?","abstract":"Preeclampsia is a multi-system disorder of pregnancy that affects 5–8% of pregnancies world-wide [[1]Rana S. Lemoine E. Granger J. Karumanchi S Preeclampsia: pathophysiology, challenges and perspectives.Circ Res. 2019; 124: 1094-1112Crossref PubMed Scopus (604) Google Scholar, [2]Amaral L. Wallace K. Owens M. Lamarca B Pathophysiology and current clinical management of preeclampsia.Curr Hypertens Rep. 2017; 19: 61Crossref PubMed Scopus (134) Google Scholar]. Preeclampsia is characterized by new-onset hypertension with other organ dysfunction such as in the kidneys or liver, or neurological disturbances, occurring after the 20th week of gestation [[3]ACOG practice bulletin No. 202: gestational hypertension and preeclampsia.Obstet Gynecol. 2019; 133: e1-e25Crossref PubMed Scopus (674) Google Scholar]. The underlying mechanisms of preeclampsia have yet to be fully elucidated. While the exact mechanism that leads to preeclampsia is still unknown, it is widely accepted that inadequate invasion of the uterine spiral arteries by cytotrophoblast cells during early pregnancy is one of the initiating events [[2]Amaral L. Wallace K. Owens M. Lamarca B Pathophysiology and current clinical management of preeclampsia.Curr Hypertens Rep. 2017; 19: 61Crossref PubMed Scopus (134) Google Scholar]. This shallow invasion of the cytotrophoblast cells leads to poor placentation and vascularization (i.e. ischemic placenta) in early pregnancy, eventually leading to systemic maternal endothelial dysfunction and immune cell activation, all thought to be the inciting processes leading to the clinical manifestations of preeclampsia [[2]Amaral L. Wallace K. Owens M. Lamarca B Pathophysiology and current clinical management of preeclampsia.Curr Hypertens Rep. 2017; 19: 61Crossref PubMed Scopus (134) Google Scholar]. Yet the molecular mechanisms that mediate this dysfunction remain under investigation. During normal pregnancies, placental autophagy (an intracellular system for bulk degradation of damaged or dysfunctional cellular components) is critical for maintenance of cellular homeostasis that is needed for embryo development [[4]Gong J. Kim G. The role of autophagy in the placenta as a regulator of cell death.Clin Exp Reprod Med. 2014; 41: 97-107Crossref PubMed Scopus (45) Google Scholar]. Autophagy is activated in response to environmental stress, however dysregulation of autophagy is associated with various diseases [[5]Saha S. Panigrahi D. Patil S. Bhutia S Autophagy in health and disease: a comprehensive review.Biomed Pharmacother. 2018; 104: 485-495Crossref PubMed Scopus (294) Google Scholar]. For example, impaired autophagy is associated with aging, neurodegenerative diseases, lysosomal disorders and cancer. In cancer, dual roles for autophagy have been described. During tumor initiation and malignant transformation, autophagy is considered to be tumor suppressive by inhibiting proliferation of cells. However, during the period of increased tumor growth, autophagy is thought to be beneficial by providing the cellular metabolites and glucose needed for proliferation and maintaining homeostasis of the tumor cells [[5]Saha S. Panigrahi D. Patil S. Bhutia S Autophagy in health and disease: a comprehensive review.Biomed Pharmacother. 2018; 104: 485-495Crossref PubMed Scopus (294) Google Scholar,[6]Salimi L. Abkari A. Jabbari N. Mojarad B. Vahhabi A. Szafert S. et al.Synergies in exosomes and autophagy pathways for cellular homeostasis and metastasis of tumor cells.Cell Biosci. 2020; 10: 64Crossref PubMed Scopus (63) Google Scholar]. Studies of autophagy in preeclampsia provide conflicting roles of this homeostatic mechanism on preeclampsia development and progression [[7]Nakashima A. Aoki A. Kusabiraki T. Cheng S. Sharma S. Saito S Autophagy regulation in preeclampsia\" pros and cons.J Reprod Immunol. 2017; 123: 17-23Crossref PubMed Scopus (43) Google Scholar]. In this issue of EBioMedicine, Zhao and colleagues report the results of a hybrid study usin","journal":"EBioMedicine","year":2020,"id":78056,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.959,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":271719,"name":"Kedra Wallace","orcid":"0000-0003-4511-0046","position":1,"is_corresponding":false},{"id":302878,"name":"Denise C. Cornelius","orcid":"0000-0002-6730-6499","position":0,"is_corresponding":true}],"reference_count":9,"raw_metadata":null,"created_at":"2026-07-18T21:49:40.769098Z","pmid":"32650269","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}