{"doi":"10.1016/j.drudis.2025.104380","title":"Advances in lipid-based nanoformulations for inhaled antibiotic therapy in respiratory infections","abstract":null,"journal":"Drug Discovery Today","year":2025,"id":608338,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1562334,"name":"Mohammad Zaki Ahmad","orcid":null,"position":1,"is_corresponding":false},{"id":1562335,"name":"Javed Ahmad","orcid":null,"position":2,"is_corresponding":false},{"id":1562336,"name":"Basel A. 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For instance, the encapsulation of inhaled antibiotics, particularly the tobramycin liposomal system, has improved efficacy and reduced toxicity, whereas the nebulized colistin nanoformulation effectively targets multidrug-resistant pathogens, including the clinical efficacy of amikacin liposome inhalation in refractory pulmonary infections. Overall, advancements in lipid-based nanoformulation and delivery technologies have significantly enhanced the utility of inhaled antibiotics, providing safer and more-effective options for managing chronic and resistant infections.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40381726","pmcid":null,"openalex_id":"https://openalex.org/W4410384806","authors":[],"funders":[{"funder_name":"Najran University","grant_id":"","title":null},{"funder_name":"Virginia Marine Resources Commission","grant_id":"","title":null}],"total_grants":2,"fwci":7.1996,"citation_percentile":0.97534417,"influential_citations":0,"citation_trend":[{"year":2025,"count":4},{"year":2026,"count":5}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1359644625000935?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1359644625000935?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.drudis.2025.104380","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40381726","host_type":"repository"}],"fields_of_study":["Inhalation and Respiratory Drug Delivery","Advanced Drug Delivery Systems","Antimicrobial Peptides and Activities"],"mesh_terms":["Administration, Inhalation","Animals","Anti-Bacterial Agents","Humans","Lipids","Liposomes","Respiratory Tract Infections","Drug Delivery Systems","Nanoparticles"],"keywords":["Medicine","Antibiotics","Antibiotic therapy","Pharmaceutical sciences","Intensive care medicine","Pharmacology","Microbiology","Biology","Antibiotic","Inhalation","Cystic Fibrosis","Clinical Trials","Pulmonary Drug Delivery","Inhalation Devices","Lipid-based Nanomedicine","Ciliary Clearance"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T12:00:36.230276Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}