{"doi":"10.1016/j.drudis.2020.02.002","title":"Impact of the Protein Data Bank on antineoplastic approvals","abstract":"Open access to 3D structure information from the Protein Data Bank (PDB) facilitated discovery and development of >90% of the 79 new antineoplastic agents (54 small molecules, 25 biologics) with known molecular targets approved by the FDA 2010-2018. Analyses of PDB holdings, the scientific literature and related documents for each drug-target combination revealed that the impact of public-domain 3D structure data was broad and substantial, ranging from understanding target biology (∼95% of all targets) to identifying a given target as probably druggable (∼95% of all targets) to structure-guided lead optimization (>70% of all small-molecule drugs). In addition to aggregate impact assessments, illustrative case studies are presented for three protein kinase inhibitors, an allosteric enzyme inhibitor and seven advanced-stage melanoma therapeutics.","journal":"Drug Discovery Today","year":2020,"id":97591,"datarank":0.8349840561456381,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"self_citation_contribution":0.5244761342199721,"citation_network_contribution":0.31050792192566595,"self_endowment_contribution":0.5244761342199721,"citer_contribution":0.31050792192566595,"corpus_percentile":75.8954127020964,"corpus_rank":3117,"citation_count":32,"citer_count":13,"citers_with_citation_signal":11,"citers_with_endowment":11,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.849,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":482713,"name":"Rose Soskind","orcid":"0000-0003-2683-6714","position":1,"is_corresponding":false},{"id":482714,"name":"Brian P. Hudson","orcid":"0000-0001-6121-9442","position":2,"is_corresponding":false},{"id":23506,"name":"S.K. Burley","orcid":"0000-0002-2487-9713","position":3,"is_corresponding":false},{"id":127,"name":"John Westbrook","orcid":"0000-0002-6686-5475","position":0,"is_corresponding":true}],"reference_count":146,"raw_metadata":null,"created_at":"2026-07-18T22:36:02.818637Z","pmid":"32068073","pmcid":"PMC7305983","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}