{"doi":"10.1016/j.dnarep.2024.103742","title":"The multifaceted roles of the Ctf4 replisome hub in the maintenance of genome integrity","abstract":"At the core of cellular life lies a carefully orchestrated interplay of DNA replication, recombination, chromatin assembly, sister-chromatid cohesion and transcription. These fundamental processes, while seemingly discrete, are inextricably linked during genome replication. A set of replisome factors integrate various DNA transactions and contribute to the transient formation of sister chromatid junctions involving either the cohesin complex or DNA four-way junctions. The latter structures serve DNA damage bypass and may have additional roles in replication fork stabilization or in marking regions of replication fork blockage. Here, we will discuss these concepts based on the ability of one replisome component, Ctf4, to act as a hub and functionally link these processes during DNA replication to ensure genome maintenance. • Ctf4 is a replisome hub connecting DNA replication with other metabolism processes. • Ctf4 interacting peptides (CIP) and other domains link replication factors to Ctf4. • Ctf4 interactions contribute to cohesion, recombination and chromatin structure.","journal":"DNA repair","year":2024,"id":461261,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9464,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1290230,"name":"Szabolcs Bene","orcid":null,"position":1,"is_corresponding":false},{"id":657111,"name":"Laxman Gangwani","orcid":"0000-0001-8575-9937","position":2,"is_corresponding":false},{"id":590314,"name":"Barnabás Szakál","orcid":"0000-0001-6888-1383","position":3,"is_corresponding":false},{"id":590313,"name":"Dana Branzei","orcid":"0000-0002-0544-4888","position":0,"is_corresponding":true}],"reference_count":106,"raw_metadata":null,"created_at":"2026-07-19T02:04:12.271488Z","pmid":"39137555","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}