{"doi":"10.1016/j.dnarep.2017.06.007","title":"BERing the burden of damage: Pathway crosstalk and posttranslational modification of base excision repair proteins regulate DNA damage management","abstract":null,"journal":"DNA Repair","year":2017,"id":640465,"datarank":0.6166310796259968,"base_score":4.110873864173311,"endowment":4.110873864173311,"self_citation_contribution":0.6166310796259968,"citation_network_contribution":0.0,"self_endowment_contribution":0.6166310796259968,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":60,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":430731,"name":"Anita H. Corbett","orcid":"0000-0002-0461-6895","position":1,"is_corresponding":false},{"id":188673,"name":"Paul W. Doetsch","orcid":null,"position":2,"is_corresponding":false},{"id":1664527,"name":"Kristin L. Limpose","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"BERing the burden of damage: Pathway crosstalk and posttranslational modification of base excision repair proteins regulate DNA damage management","abstract":"DNA base damage and non-coding apurinic/apyrimidinic (AP) sites are ubiquitous types of damage that must be efficiently repaired to prevent mutations. These damages can occur in both the nuclear and mitochondrial genomes. Base excision repair (BER) is the frontline pathway for identifying and excising damaged DNA bases in both of these cellular compartments. Recent advances demonstrate that BER does not operate as an isolated pathway but rather dynamically interacts with components of other DNA repair pathways to modulate and coordinate BER functions. We define the coordination and interaction between DNA repair pathways as pathway crosstalk. Numerous BER proteins are modified and regulated by post-translational modifications (PTMs), and PTMs could influence pathway crosstalk. Here, we present recent advances on BER/DNA repair pathway crosstalk describing specific examples and also highlight regulation of BER components through PTMs. We have organized and reported functional interactions and documented PTMs for BER proteins into a consolidated summary table. We further propose the concept of DNA repair hubs that coordinate DNA repair pathway crosstalk to identify central protein targets that could play a role in designing future drug targets.","is_dataset_classified":null,"base_score":4.110873864173311,"endowment":4.110873864173311,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28629773","pmcid":"PMC5576989","openalex_id":"https://openalex.org/W2621549033","authors":[],"funders":[{"funder_name":"(PWD)","grant_id":"ESES011163","title":null},{"funder_name":"(AHC)","grant_id":"GM058728","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM058728","title":null},{"funder_name":"NIEHS NIH HHS","grant_id":"P01 ES011163","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P20 CA103735","title":null}],"total_grants":5,"fwci":2.2308,"citation_percentile":0.88575349,"influential_citations":0,"citation_trend":[{"year":2018,"count":7},{"year":2019,"count":7},{"year":2020,"count":8},{"year":2021,"count":12},{"year":2022,"count":8},{"year":2023,"count":5},{"year":2024,"count":3},{"year":2025,"count":7},{"year":2026,"count":3}],"oa_status":"green","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5576989","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5576989","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S1568786417302070?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1568786417302070?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.dnarep.2017.06.007","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28629773","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC5576989","host_type":"repository"}],"fields_of_study":["DNA Repair Mechanisms","PARP inhibition in cancer therapy","Genetics and Neurodevelopmental Disorders"],"mesh_terms":["Animals","DNA Damage","DNA Repair","Humans","Protein Processing, Post-Translational","Signal Transduction","DNA Repair Enzymes","Eukaryota"],"keywords":["Crosstalk","Base excision repair","AP site","DNA repair","Biology","DNA damage","Cell biology","DNA","Computational biology","Nucleotide excision repair","Genetics","Base Excision Repair Ber","Dna Pathway Crosstalk","Dna Repair Hubs","Post-translational Modifications Ptms"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T12:01:58.248733Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}