{"doi":"10.1016/j.dnarep.2006.10.002","title":"XRCC1 interactions with base excision repair DNA intermediates","abstract":null,"journal":"DNA Repair","year":2007,"id":675644,"datarank":3.644041494100724,"base_score":4.584967478670572,"endowment":4.584967478670572,"self_citation_contribution":0.687745121800586,"citation_network_contribution":2.956296372300138,"self_endowment_contribution":0.687745121800586,"citer_contribution":2.956296372300138,"corpus_percentile":null,"corpus_rank":null,"citation_count":97,"citer_count":74,"citers_with_citation_signal":68,"citers_with_endowment":68,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":169599,"name":"Svetlana N. Khodyreva","orcid":null,"position":1,"is_corresponding":false},{"id":1765341,"name":"Stéphanie Marsin","orcid":null,"position":2,"is_corresponding":false},{"id":588919,"name":"Olga I. Lavrik","orcid":"0000-0001-5980-8889","position":3,"is_corresponding":false},{"id":183099,"name":"J. Pablo Radicella","orcid":null,"position":4,"is_corresponding":false},{"id":1765340,"name":"Zhanna K. Nazarkina","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"XRCC1 interactions with base excision repair DNA intermediates","abstract":"Abasic (AP) sites in DNA arise either spontaneously, or through glycosylase-catalyzed excision of damaged bases. Their removal by the base excision repair (BER) pathway avoids their mutagenic and cytotoxic consequences. XRCC1 coordinates and facilitates single-strand break (SSB) repair and BER in mammalian cells. We report that XRCC1, through its NTD and BRCT1 domains, has affinity for several DNA intermediates in BER. As shown by its capacity to form a covalent complex via Schiff base, XRCC1 binds AP sites. APE1 suppresses binding of XRCC1 to unincised AP sites however, affinity was higher when the DNA carried an AP-lyase- or APE1-incised AP site. The AP site binding capacity of XRCC1 is enhanced by the presence of strand interruptions in the opposite strand. Binding of XRCC1 to BER DNA intermediates could play an important role to warrant the accurate repair of damaged bases, AP sites or SSBs, in particular in the context of clustered DNA damage.","is_dataset_classified":null,"base_score":4.584967478670572,"endowment":4.584967478670572,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17118717","pmcid":null,"openalex_id":"https://openalex.org/W1966471693","authors":[],"funders":[],"total_grants":0,"fwci":1.906,"citation_percentile":0.83969352,"influential_citations":0,"citation_trend":[{"year":2012,"count":7},{"year":2013,"count":3},{"year":2014,"count":2},{"year":2015,"count":9},{"year":2016,"count":8},{"year":2017,"count":3},{"year":2018,"count":3},{"year":2019,"count":7},{"year":2020,"count":9},{"year":2021,"count":3},{"year":2022,"count":4},{"year":2023,"count":4},{"year":2024,"count":5},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1568786406003090?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1568786406003090?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.dnarep.2006.10.002","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17118717","host_type":"repository"},{"url":"https://hal.science/hal-00169619","host_type":"repository"}],"fields_of_study":["DNA Repair Mechanisms","DNA and Nucleic Acid Chemistry","Carcinogens and Genotoxicity Assessment"],"mesh_terms":["X-ray Repair Cross Complementing Protein 1","Animals","Base Sequence","Binding Sites","Cricetulus","DNA Repair","DNA-Binding Proteins","Cricetinae","Humans","Oligodeoxyribonucleotides","Recombinant Proteins","CHO Cells","DNA-(Apurinic or Apyrimidinic Site) Lyase","DNA Glycosylases","In Vitro Techniques"],"keywords":["XRCC1","Base excision repair","AP endonuclease","Biology","DNA glycosylase","AP site","DNA repair","DNA","DNA damage","Context (archaeology)","Nucleotide excision repair","Base pair","Biochemistry","Molecular biology","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T01:31:18.599298Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}