{"doi":"10.1016/j.diagmicrobio.2015.01.010","title":"Comparison of the in vitro activity of echinocandins against Candida albicans , Candida dubliniensis , and Candida africana by time–kill curves","abstract":null,"journal":"Diagnostic Microbiology and Infectious Disease","year":2015,"id":605101,"datarank":0.47032413238937254,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.0,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1552853,"name":"Nerea Jauregizar","orcid":null,"position":1,"is_corresponding":false},{"id":1552854,"name":"Emilia Cantón","orcid":"0000-0002-6084-8375","position":2,"is_corresponding":false},{"id":498071,"name":"Elena Eraso","orcid":"0000-0002-9043-9265","position":3,"is_corresponding":false},{"id":1552855,"name":"Guillermo Quindós","orcid":"0000-0002-4657-2261","position":4,"is_corresponding":false},{"id":1552852,"name":"Sandra Gil-Alonso","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Comparison of the in vitro activity of echinocandins against Candida albicans , Candida dubliniensis , and Candida africana by time–kill curves","abstract":"Candida albicans remains the most common fungal pathogen. This species is closely related to 2 phenotypically similar cryptic species, Candida dubliniensis and Candida africana. This study aims to compare the antifungal activities of echinocandins against 7 C. albicans, 5 C. dubliniensis, and 2 C. africana strains by time-kill methodology. MIC values were similar for the 3 species; however, differences in killing activity were observed among species, isolates, and echinocandins. Echinocandins produced weak killing activity against the 3 species. In all drugs, the fungicidal endpoint (99.9% mortality) was reached at ≤31 h with ≥0.5 μg/mL for anidulafungin in 4 C. albicans and 1 C. dubliniensis, for caspofungin in 1 C. albicans and 2 C. dubliniensis, and for micafungin in 4 C. albicans and 1 C. dubliniensis. None of echinocandins showed lethality against C. africana. Identification of these new cryptic species and time-kill studies would be recommendable when echinocandin treatment fails.","is_dataset_classified":null,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25703894","pmcid":null,"openalex_id":"https://openalex.org/W1995191980","authors":[],"funders":[{"funder_name":"Consejería de Educación, Universidades e Investigación","grant_id":"GIC12 210-IT-696-13","title":null},{"funder_name":"Gobierno Vasco-Eusko Jaurlaritza","grant_id":"S-PR12UN002","title":null},{"funder_name":"Gobierno Vasco-Eusko Jaurlaritza","grant_id":"S-PE13UN121","title":null},{"funder_name":"Fondo de Investigación Sanitaria","grant_id":"FIS PI11/00203","title":null},{"funder_name":"UPV/EHU","grant_id":"UFI 11/25","title":null}],"total_grants":5,"fwci":1.5492,"citation_percentile":0.81705007,"influential_citations":0,"citation_trend":[{"year":2015,"count":1},{"year":2016,"count":3},{"year":2017,"count":2},{"year":2018,"count":2},{"year":2019,"count":5},{"year":2020,"count":2},{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0732889315000267?httpAccept=text/plain","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0732889315000267?httpAccept=text/xml","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.diagmicrobio.2015.01.010","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25703894","host_type":"repository"}],"fields_of_study":["Antifungal resistance and susceptibility","Plant Pathogens and Fungal Diseases","Essential Oils and Antimicrobial Activity","Antifungal Agents","Candida","Echinocandins","Humans","Microbial Sensitivity Tests","Microbial Viability","Time Factors"],"mesh_terms":["Antifungal Agents","Candida","Humans","Microbial Sensitivity Tests","Time Factors","Microbial Viability","Echinocandins"],"keywords":["Candida dubliniensis","Echinocandins","Micafungin","Anidulafungin","Echinocandin","Caspofungin","Candida albicans","Microbiology","Biology","Corpus albicans","Amphotericin B","Antifungal","Fluconazole","Time-kill","Candida Africana"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T01:38:52.483722Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}