{"doi":"10.1016/j.diabres.2004.07.010","title":"The effect of improved post-prandial blood glucose control on post-prandial metabolism and markers of vascular risk in people with Type 2 diabetes","abstract":null,"journal":"Diabetes Research and Clinical Practice","year":2005,"id":676204,"datarank":1.73169077945086,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":1.2373152495502107,"self_endowment_contribution":0.4943755299006494,"citer_contribution":1.2373152495502107,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":24,"citers_with_citation_signal":20,"citers_with_endowment":20,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1766865,"name":"P.D. Home","orcid":null,"position":1,"is_corresponding":false},{"id":1344250,"name":"A. Gallagher","orcid":"0009-0002-9918-5174","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The effect of improved post-prandial blood glucose control on post-prandial metabolism and markers of vascular risk in people with Type 2 diabetes","abstract":"A variety of abnormalities of metabolic, haemostatic and endothelial markers are associated with Type 2 diabetes. Evidence suggests that poor post-prandial blood glucose control may contribute to vascular risk. We aimed to examine whether the restoration of a more physiological insulin profile post-prandially would improve these abnormalities. Twenty-one patients with insulin-treated Type 2 diabetes were recruited into a single centre, crossover, double-blind study. Patients were randomized to unmodified human insulin or insulin aspart before main meals for 6-week study periods, both together with NPH insulin. At the end of each study period, pre-breakfast levels of markers of vascular risk were assessed and a test meal performed. There was no significant difference in HbA(1c) (7.04 +/- 0.13% (+/-S.E.) versus 7.15 +/- 0.11%, P = 0.060) with insulin aspart compared to human insulin at the end of each study period. The mean post-prandial blood glucose concentration at 90 min from self-monitored results was lower with insulin aspart than with human insulin (7.9 +/- 0.4 mmol/l versus 9.3 +/- 0.4 mmol/l, P = 0.011) as was study day post-prandial blood glucose at 90 min (8.4 +/- 0.5 mmol/l versus 9.2 +/- 0.6 mmol/l, P = 0.046). No significant differences were found in fasting lipid profile, apolipoproteins, fibrinogen, plasminogen activator inhibitor-1, E-selectin, or homocysteine between the two study periods. Insulin aspart resulted in improved post-prandial glycaemic control when compared to human insulin in Type 2 diabetic patients, but this was not associated with changes in markers of vascular risk.","is_dataset_classified":null,"base_score":3.295836866004329,"endowment":3.295836866004329,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15713351","pmcid":null,"openalex_id":"https://openalex.org/W2111618872","authors":[],"funders":[{"funder_name":"Novo Nordisk","grant_id":"","title":null}],"total_grants":1,"fwci":1.27,"citation_percentile":0.80486248,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":1},{"year":2015,"count":3},{"year":2021,"count":2},{"year":2023,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0168822704002128?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0168822704002128?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.diabres.2004.07.010","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15713351","host_type":"repository"}],"fields_of_study":["Diabetes, Cardiovascular Risks, and Lipoproteins","Cardiovascular Function and Risk Factors","Cardiac Imaging and Diagnostics","Aged","Blood Glucose","Blood Glucose Self-Monitoring","Body Mass Index","Cholesterol","Cross-Over Studies","Diabetes Mellitus, Type 2","Diabetic Angiopathies","Double-Blind Method","Female","Homocysteine","Humans","Hypoglycemic Agents","Insulin","Insulin Aspart","Lipoproteins","Male","Postprandial Period","Risk Factors"],"mesh_terms":["Aged","Blood Glucose","Cholesterol","Diabetes Mellitus, Type 2","Diabetic Angiopathies","Double-Blind Method","Female","Homocysteine","Humans","Hypoglycemic Agents","Insulin","Lipoproteins","Male","Risk Factors","Blood Glucose Self-Monitoring","Body Mass Index","Cross-Over Studies","Postprandial Period","Insulin Aspart"],"keywords":["Post-prandial","Medicine","Type 2 diabetes","Diabetes mellitus","Internal medicine","Endocrinology","Type 2 Diabetes Mellitus","Carbohydrate metabolism"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T02:14:23.439862Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}