{"doi":"10.1016/j.devcel.2025.08.017","title":"Maternal CENP-C restores centromere symmetry in mammalian zygotes to ensure proper chromosome segregation","abstract":"Across metazoan species, the centromere-specific histone variant CENP-A is essential for accurate chromosome segregation, yet its regulation during the mammalian parental-to-zygote transition is poorly understood. To address this, we generated a CENP-A-mScarlet mouse model that revealed sex-specific dynamics: mature sperm retain 10% of the CENP-A levels present in MII oocytes. However, this difference is resolved in zygotes prior to the first mitosis, using maternally inherited cytoplasmic CENP-A. Notably, the increase in CENP-A at paternal centromeres is independent of sensing CENP-A asymmetry or the presence of maternal chromosomes. Instead, CENP-A equalization relies on the asymmetric recruitment of maternal CENP-C to paternal centromeres. Depletion of maternal CENP-A decreases total CENP-A in both pronuclei without disrupting equalization. In contrast, reducing maternal CENP-C or disruption of its dimerization function impairs CENP-A equalization and chromosome segregation. Therefore, maternal CENP-C acts as a key epigenetic regulator that resets centromeric symmetry at fertilization to preserve genome integrity.","journal":"Developmental Cell","year":2025,"id":526972,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9477,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":235830,"name":"Gabriel Manske","orcid":"0000-0001-5461-4647","position":1,"is_corresponding":false},{"id":1403098,"name":"Emily Lenk Ferrell","orcid":"0009-0008-9721-3868","position":2,"is_corresponding":false},{"id":814291,"name":"Dilara N. Anbarci","orcid":"0000-0003-0435-4749","position":3,"is_corresponding":false},{"id":806509,"name":"Kelsey Jorgensen","orcid":"0000-0002-8681-5248","position":4,"is_corresponding":false},{"id":391991,"name":"Bin Ma","orcid":"0009-0003-1048-4459","position":5,"is_corresponding":false},{"id":719640,"name":"Mansour Aboelenain","orcid":"0000-0002-3806-6748","position":6,"is_corresponding":false},{"id":819935,"name":"Rajesh Ranjan","orcid":"0000-0003-1368-6067","position":7,"is_corresponding":false},{"id":988306,"name":"Saikat Chakraborty","orcid":"0000-0002-2908-7205","position":8,"is_corresponding":false},{"id":658347,"name":"Lindsay Moritz","orcid":"0000-0001-6704-8453","position":9,"is_corresponding":false},{"id":719117,"name":"Arunika Das","orcid":"0000-0001-7116-3489","position":10,"is_corresponding":false},{"id":1403099,"name":"Michele Boiani","orcid":"0000-0003-2765-2781","position":11,"is_corresponding":false},{"id":232713,"name":"Ben E. Black","orcid":"0000-0002-3707-9483","position":12,"is_corresponding":false},{"id":64732,"name":"Shawn L. Chavez","orcid":"0000-0002-8285-0222","position":13,"is_corresponding":false},{"id":109741,"name":"Erica E. Marsh","orcid":"0000-0003-1331-6525","position":14,"is_corresponding":false},{"id":237466,"name":"Ariella Shikanov","orcid":"0000-0003-0159-6419","position":15,"is_corresponding":false},{"id":298427,"name":"Karen Schindler","orcid":"0000-0001-6113-1184","position":16,"is_corresponding":false},{"id":463359,"name":"Xin Chen","orcid":"0000-0002-6990-0926","position":17,"is_corresponding":false},{"id":235835,"name":"Saher Sue Hammoud","orcid":"0000-0002-5040-6370","position":18,"is_corresponding":false},{"id":502949,"name":"Catherine A. Tower","orcid":"0000-0003-4470-6227","position":0,"is_corresponding":true}],"reference_count":102,"raw_metadata":null,"created_at":"2026-07-19T02:50:34.851930Z","pmid":"40997799","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}