{"doi":"10.1016/j.devcel.2025.05.007","title":"ATG9A and ARFIP2 cooperate to control PI4P levels for lysosomal repair","abstract":"Lysosome damage activates multiple pathways to prevent lysosome-dependent cell death, including a repair mechanism involving endoplasmic reticulum (ER)-lysosome membrane contact sites, phosphatidylinositol 4-kinase-2a (PI4K2A), phosphatidylinositol-4 phosphate (PI4P), and oxysterol-binding protein-like proteins (OSBPLs) lipid transfer proteins. PI4K2A localizes to the trans-Golgi network and endosomes, yet how it is delivered to damaged lysosomes remains unknown. During acute sterile damage and damage caused by intracellular bacteria, we show that ATG9A-containing vesicles perform a critical role in delivering PI4K2A to damaged lysosomes. ADP ribosylation factor interacting protein 2 (ARFIP2), a component of ATG9A vesicles, binds and sequesters PI4P on lysosomes, balancing OSBPL-dependent lipid transfer and promoting the retrieval of ATG9A vesicles through the recruitment of the adaptor protein complex-3 (AP-3). Our results identify a role for mobilized ATG9A vesicles and ARFIP2 in lysosome homeostasis after damage and bacterial infection.","journal":"Developmental Cell","year":2025,"id":510012,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9413,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":356671,"name":"Eugènia Almacellas","orcid":"0000-0002-7726-8430","position":1,"is_corresponding":false},{"id":1366032,"name":"Daniel Dai Yu","orcid":null,"position":2,"is_corresponding":false},{"id":1366033,"name":"Emily Millard","orcid":null,"position":3,"is_corresponding":false},{"id":1117066,"name":"Wenxin Zhang","orcid":"0000-0002-7657-4495","position":4,"is_corresponding":false},{"id":1365251,"name":"Cecilia de Heus","orcid":"0000-0001-8618-8451","position":5,"is_corresponding":false},{"id":893564,"name":"Christophe J. Queval","orcid":null,"position":6,"is_corresponding":false},{"id":1365252,"name":"Javier H. Hervás","orcid":"0000-0002-6850-7938","position":7,"is_corresponding":false},{"id":1079772,"name":"Enrica Pellegrino","orcid":"0000-0002-3918-2310","position":8,"is_corresponding":false},{"id":1332782,"name":"Ioanna Panagi","orcid":null,"position":9,"is_corresponding":false},{"id":1365253,"name":"Ditte Louise Fogde","orcid":"0000-0002-9705-4894","position":10,"is_corresponding":false},{"id":1287009,"name":"Teresa L. M. Thurston","orcid":"0000-0001-6139-3723","position":11,"is_corresponding":false},{"id":560410,"name":"Judith Klumperman","orcid":"0000-0003-4835-6228","position":12,"is_corresponding":false},{"id":1201127,"name":"Maximiliano G. Gutiérrez","orcid":"0000-0003-3199-0337","position":13,"is_corresponding":false},{"id":639023,"name":"Sharon A. Tooze","orcid":"0000-0002-2182-3116","position":14,"is_corresponding":false},{"id":1365250,"name":"Stefano De Tito","orcid":"0000-0002-9493-9371","position":0,"is_corresponding":true}],"reference_count":86,"raw_metadata":null,"created_at":"2026-07-19T02:47:30.942539Z","pmid":"40460835","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}