{"doi":"10.1016/j.devcel.2022.05.003","title":"A human breast atlas integrating single-cell proteomics and transcriptomics","abstract":"The breast is a dynamic organ whose response to physiological and pathophysiological conditions alters its disease susceptibility, yet the specific effects of these clinical variables on cell state remain poorly annotated. We present a unified, high-resolution breast atlas by integrating single-cell RNA-seq, mass cytometry, and cyclic immunofluorescence, encompassing a myriad of states. We define cell subtypes within the alveolar, hormone-sensing, and basal epithelial lineages, delineating associations of several subtypes with cancer risk factors, including age, parity, and BRCA2 germline mutation. Of particular interest is a subset of alveolar cells termed basal-luminal (BL) cells, which exhibit poor transcriptional lineage fidelity, accumulate with age, and carry a gene signature associated with basal-like breast cancer. We further utilize a medium-depletion approach to identify molecular factors regulating cell-subtype proportion in organoids. Together, these data are a rich resource to elucidate diverse mammary cell states.","journal":"Developmental Cell","year":2022,"id":11892,"datarank":3.202177814068783,"base_score":5.099866427824199,"endowment":5.099866427824199,"self_citation_contribution":0.7649799641736299,"citation_network_contribution":2.4371978498951528,"self_endowment_contribution":0.7649799641736299,"citer_contribution":2.4371978498951528,"corpus_percentile":93.09971377736521,"corpus_rank":893,"citation_count":163,"citer_count":100,"citers_with_citation_signal":96,"citers_with_endowment":96,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.8659,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-06-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":51539,"name":"Carman Man-Chung Li","orcid":"0000-0002-0577-7797","position":1,"is_corresponding":false},{"id":95403,"name":"Jennifer M. Rosenbluth","orcid":"0000-0003-1314-6976","position":2,"is_corresponding":false},{"id":51544,"name":"Laura M. Selfors","orcid":"0000-0002-1317-7353","position":3,"is_corresponding":false},{"id":51546,"name":"Nomeda Girnius","orcid":"0000-0002-7267-5950","position":4,"is_corresponding":false},{"id":95404,"name":"Ron C.J. Schackmann","orcid":"0000-0003-0461-7369","position":6,"is_corresponding":false},{"id":95405,"name":"Walter L. Goh","orcid":null,"position":7,"is_corresponding":false},{"id":95406,"name":"Kaitlin Moore","orcid":"0000-0001-6248-1522","position":8,"is_corresponding":false},{"id":95408,"name":"Shaolin Mei","orcid":"0000-0002-2193-764X","position":10,"is_corresponding":false},{"id":95409,"name":"Kurt D’Andrea","orcid":"0000-0001-7005-3800","position":11,"is_corresponding":false},{"id":95410,"name":"Katherine L. Nathanson","orcid":"0000-0002-6740-0901","position":12,"is_corresponding":false},{"id":24147,"name":"Peter K. Sorger","orcid":"0000-0002-3364-1838","position":13,"is_corresponding":false},{"id":70392,"name":"Sandro Santagata","orcid":"0000-0002-7528-9668","position":14,"is_corresponding":false},{"id":29633,"name":"Prisca Liberali","orcid":"0000-0003-0695-6081","position":15,"is_corresponding":false},{"id":95411,"name":"Judy E. Garber","orcid":"0000-0001-9449-3982","position":16,"is_corresponding":false},{"id":95412,"name":"Deborah A. Dillon","orcid":null,"position":17,"is_corresponding":false},{"id":3226,"name":"Joan S. Brugge","orcid":"0000-0002-2547-4814","position":18,"is_corresponding":false},{"id":24150,"name":"Jia‐Ren Lin","orcid":"0000-0003-4702-7705","position":19,"is_corresponding":false},{"id":51549,"name":"Hana Shapiro","orcid":"0000-0002-7917-5190","position":20,"is_corresponding":false},{"id":74572,"name":"Deborah Dillon","orcid":"0000-0002-4977-6673","position":21,"is_corresponding":false},{"id":95402,"name":"G. Kenneth Gray","orcid":"0000-0003-4969-670X","position":0,"is_corresponding":true}],"reference_count":194,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":"35617956","pmcid":"PMC9202341","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}