{"doi":"10.1016/j.devcel.2018.12.016","title":"The Lin28/let-7 Pathway Regulates the Mammalian Caudal Body Axis Elongation Program","abstract":null,"journal":"Developmental Cell","year":2019,"id":688646,"datarank":0.6496100010429497,"base_score":4.330733340286331,"endowment":4.330733340286331,"self_citation_contribution":0.6496100010429497,"citation_network_contribution":0.0,"self_endowment_contribution":0.6496100010429497,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":75,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":921991,"name":"Jérome Chal","orcid":"0000-0002-0468-7677","position":1,"is_corresponding":false},{"id":48122,"name":"Edroaldo Lummertz da Rocha","orcid":"0000-0003-0537-4223","position":2,"is_corresponding":false},{"id":270299,"name":"Areum Han","orcid":"0000-0001-5949-4672","position":3,"is_corresponding":false},{"id":1799076,"name":"Alena V. Yermalovich","orcid":null,"position":4,"is_corresponding":false},{"id":250289,"name":"Masayuki Oginuma","orcid":"0000-0003-0912-5187","position":5,"is_corresponding":false},{"id":240011,"name":"Thorsten M. Schlaeger","orcid":"0000-0002-1599-9908","position":6,"is_corresponding":false},{"id":270298,"name":"Patricia Sousa","orcid":"0000-0001-6153-9518","position":7,"is_corresponding":false},{"id":1336428,"name":"Antony Rodriguez","orcid":"0000-0002-6649-1856","position":8,"is_corresponding":false},{"id":1798139,"name":"Achia Urbach","orcid":null,"position":9,"is_corresponding":false},{"id":219569,"name":"Olivier Pourquié","orcid":null,"position":10,"is_corresponding":false},{"id":3648,"name":"George Q. Daley","orcid":"0000-0002-6346-5919","position":11,"is_corresponding":false},{"id":1799075,"name":"Daisy A. Robinton","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Lin28/let-7 Pathway Regulates the Mammalian Caudal Body Axis Elongation Program","abstract":"The heterochronic genes Lin28a/b and let-7 regulate invertebrate development, but their functions in patterning the mammalian body plan remain unexplored. Here, we describe how Lin28/let-7 influence caudal vertebrae number during body axis formation. We found that FoxD1-driven overexpression of Lin28a strikingly increased caudal vertebrae number and tail bud cell proliferation, whereas its knockout did the opposite. Lin28a overexpression downregulated the neural marker Sox2, causing a pro-mesodermal phenotype with a decreased proportion of neural tissue relative to nascent mesoderm. Manipulating Lin28a and let-7 led to opposite effects, and manipulating Lin28a's paralog, LIN28B caused similar yet distinct phenotypes. These findings suggest that Lin28/let-7 play a role in the regulation of tail length through heterochrony of the body plan. We propose that the Lin28/let-7 pathway controls the pool of caudal progenitors during tail development, promoting their self-renewal and balancing neural versus mesodermal cell fate decisions.","is_dataset_classified":null,"base_score":4.330733340286331,"endowment":4.330733340286331,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30661985","pmcid":null,"openalex_id":"https://openalex.org/W2910501032","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"NIH-P30-HD 18655","title":null},{"funder_name":"National Institutes of Health","grant_id":"R01GM107536","title":null},{"funder_name":"NCI NIH HHS","grant_id":"F99 CA212487","title":null},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null}],"total_grants":5,"fwci":3.2703,"citation_percentile":0.9329474,"influential_citations":0,"citation_trend":[{"year":2019,"count":8},{"year":2020,"count":12},{"year":2021,"count":13},{"year":2022,"count":10},{"year":2023,"count":12},{"year":2024,"count":12},{"year":2025,"count":4},{"year":2026,"count":4}],"oa_status":"bronze","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"http://www.cell.com/article/S1534580718310840/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S1534580718310840/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1534580718310840?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1534580718310840?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.devcel.2018.12.016","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30661985","host_type":"repository"}],"fields_of_study":["Developmental Biology and Gene Regulation","Congenital heart defects research","Aquatic life and conservation","Animals","Cell Differentiation","Cell Proliferation","Mammals","Mice, Transgenic","MicroRNAs","Morphogenesis","RNA-Binding Proteins"],"mesh_terms":["Animals","Cell Differentiation","Mammals","Mice, Transgenic","Morphogenesis","RNA-Binding Proteins","MicroRNAs","Cell Proliferation"],"keywords":["LIN28","Biology","Heterochrony","Mesoderm","Body plan","Phenotype","SOX2","Cell biology","Progenitor","Anatomy","Progenitor cell","Genetics","Stem cell","Gene","Embryo","Embryonic stem cell","Development","Cell Fate","Somitogenesis","Let-7 Mirna","Body Axis Elongation","Tail Bud"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-19T18:15:43.441865Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}