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Using a combination of cell biological approaches and in vitro reconstitution of competition between actin assembly factors, we found that the small G-actin binding protein profilin directly inhibits Arp2/3 complex-mediated actin assembly. Profilin is therefore required for formin to compete effectively with excess Arp2/3 complex for limited G-actin and to assemble F-actin for contractile ring formation in dividing cells.","is_dataset_classified":null,"base_score":5.579729825986222,"endowment":5.579729825986222,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25543282","pmcid":"PMC4293355","openalex_id":"https://openalex.org/W2163455170","authors":[],"funders":[{"funder_name":"NCATS NIH HHS","grant_id":"UL1 TR000430","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM007183","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM079265","title":null}],"total_grants":3,"fwci":11.0996,"citation_percentile":0.99276822,"influential_citations":0,"citation_trend":[{"year":2014,"count":2},{"year":2015,"count":21},{"year":2016,"count":30},{"year":2017,"count":26},{"year":2018,"count":23},{"year":2019,"count":28},{"year":2020,"count":35},{"year":2021,"count":25},{"year":2022,"count":22},{"year":2023,"count":20},{"year":2024,"count":11},{"year":2025,"count":14},{"year":2026,"count":7}],"oa_status":"bronze","license":"https://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"http://www.cell.com/article/S1534580714006935/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S1534580714006935/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1534580714006935?httpAccept=text/plain","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1534580714006935?httpAccept=text/xml","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.devcel.2014.10.027","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25543282","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4293355","host_type":"repository"}],"fields_of_study":["Cellular Mechanics and Interactions","Fungal and yeast genetics research","Advanced Fluorescence Microscopy Techniques","Actin Cytoskeleton","Actin-Related Protein 2-3 Complex","Actins","Endocytosis","Homeostasis","Image Processing, Computer-Assisted","Microscopy, Fluorescence","Profilins","Schizosaccharomyces","Schizosaccharomyces pombe Proteins"],"mesh_terms":["Actins","Endocytosis","Homeostasis","Image Processing, Computer-Assisted","Actin Cytoskeleton","Microscopy, Fluorescence","Schizosaccharomyces","Schizosaccharomyces pombe Proteins","Profilins","Actin-Related Protein 2-3 Complex"],"keywords":["Formins","Profilin","MDia1","Biology","Actin remodeling","Cell biology","Actin","Actin cytoskeleton","Actin remodeling of neurons","Actin-binding protein","Cytoskeleton","Cell","Biochemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-19T09:27:37.178868Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}