{"doi":"10.1016/j.devcel.2014.06.013","title":"TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition","abstract":null,"journal":"Developmental Cell","year":2014,"id":657914,"datarank":9.727468739294649,"base_score":5.814130531825066,"endowment":5.814130531825066,"self_citation_contribution":0.8721195797737601,"citation_network_contribution":8.85534915952089,"self_endowment_contribution":0.8721195797737601,"citer_contribution":8.85534915952089,"corpus_percentile":null,"corpus_rank":null,"citation_count":334,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":14,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1431368,"name":"Ashish Jain","orcid":"0000-0002-8413-5687","position":1,"is_corresponding":false},{"id":1717463,"name":"John Arko-Mensah","orcid":null,"position":2,"is_corresponding":false},{"id":897635,"name":"Santosh Chauhan","orcid":"0000-0001-9167-5107","position":3,"is_corresponding":false},{"id":1631192,"name":"Tomonori Kimura","orcid":null,"position":4,"is_corresponding":false},{"id":1717464,"name":"Christina Dinkins","orcid":null,"position":5,"is_corresponding":false},{"id":233497,"name":"Guido Silvestri","orcid":"0000-0001-6602-2470","position":6,"is_corresponding":false},{"id":568454,"name":"Jan Münch","orcid":"0000-0001-7316-7141","position":7,"is_corresponding":false},{"id":12190,"name":"Frank Kirchhoff","orcid":"0000-0002-2324-2761","position":8,"is_corresponding":false},{"id":232590,"name":"Anne Simonsen","orcid":"0000-0003-4711-7057","position":9,"is_corresponding":false},{"id":976130,"name":"Yongjie Wei","orcid":null,"position":10,"is_corresponding":false},{"id":49719,"name":"Beth Levine","orcid":"0000-0002-1460-1638","position":11,"is_corresponding":false},{"id":227840,"name":"Terje Johansen","orcid":"0000-0003-1451-9578","position":12,"is_corresponding":false},{"id":1359416,"name":"Vojo Deretic","orcid":null,"position":13,"is_corresponding":false},{"id":1717462,"name":"Michael A. Mandell","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition","abstract":"Autophagy, a homeostatic process whereby eukaryotic cells target cytoplasmic cargo for degradation, plays a broad role in health and disease states. Here we screened the TRIM family for roles in autophagy and found that half of TRIMs modulated autophagy. In mechanistic studies, we show that TRIMs associate with autophagy factors and act as platforms assembling ULK1 and Beclin 1 in their activated states. Furthermore, TRIM5α acts as a selective autophagy receptor. Based on direct sequence-specific recognition, TRIM5α delivered its cognate cytosolic target, a viral capsid protein, for autophagic degradation. Thus, our study establishes that TRIMs can function both as regulators of autophagy and as autophagic cargo receptors, and reveals a basis for selective autophagy in mammalian cells.","is_dataset_classified":null,"base_score":5.814130531825066,"endowment":5.814130531825066,"datacite_reuse_total":14,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25127057","pmcid":"PMC4146662","openalex_id":"https://openalex.org/W2127187639","authors":[],"funders":[{"funder_name":"NCATS NIH HHS","grant_id":"UL1 TR000041","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"AI042999","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R37 AI042999","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"T32AI007538","title":null},{"funder_name":"NIH HHS","grant_id":"P51OD011132","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R56 CA109618","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 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