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Recent studies have provided detailed information on how angiogenic sprouts initiate, elongate, and branch, but less is known about how these processes cease. Here, we show that S1PR1, a receptor for the blood-borne bioactive lipid sphingosine-1-phosphate (S1P), is critical for inhibition of angiogenesis and acquisition of vascular stability. Loss of S1PR1 leads to increased endothelial cell sprouting and the formation of ectopic vessel branches. Conversely, S1PR1 signaling inhibits angiogenic sprouting and enhances cell-to-cell adhesion. This correlates with inhibition of vascular endothelial growth factor-A (VEGF-A)-induced signaling and stabilization of vascular endothelial (VE)-cadherin localization at endothelial junctions. Our data suggest that S1PR1 signaling acts as a vascular-intrinsic stabilization mechanism, protecting developing blood vessels against aberrant angiogenic responses.","is_dataset_classified":null,"base_score":5.799092654460526,"endowment":5.799092654460526,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22975327","pmcid":null,"openalex_id":"https://openalex.org/W1969788014","authors":[],"funders":[],"total_grants":0,"fwci":10.0639,"citation_percentile":0.98937415,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":29},{"year":2014,"count":26},{"year":2015,"count":23},{"year":2016,"count":23},{"year":2017,"count":23},{"year":2018,"count":17},{"year":2019,"count":24},{"year":2020,"count":38},{"year":2021,"count":26},{"year":2022,"count":25},{"year":2023,"count":27},{"year":2024,"count":23},{"year":2025,"count":12},{"year":2026,"count":9}],"oa_status":"bronze","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"http://www.cell.com/article/S1534580712003735/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S1534580712003735/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1534580712003735?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1534580712003735?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.devcel.2012.08.005","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22975327","host_type":"repository"},{"url":"http://edoc.mpg.de/648332","host_type":"repository"}],"fields_of_study":["Sphingolipid Metabolism and Signaling","Axon Guidance and Neuronal Signaling","Hippo pathway signaling and YAP/TAZ"],"mesh_terms":["Sphingosine-1-Phosphate Receptors","Cadherin 5","Animals","Cells, Cultured","Humans","Mice, Transgenic","Zebrafish","Antigens, CD","Cadherins","Mice, Knockout","Neovascularization, Physiologic","Vascular Endothelial Growth Factor Receptor-2","Endothelial Cells","Receptors, Lysosphingolipid","Mice"],"keywords":["S1PR1","Biology","Angiogenesis","Sphingosine-1-phosphate","VE-cadherin","Cell biology","Sprouting angiogenesis","VEGF receptors","Receptor","Cadherin","Sphingosine","Cancer research","Neovascularization","Biochemistry","Vascular endothelial growth factor A","Vascular endothelial growth factor"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T02:18:25.794596Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}