{"doi":"10.1016/j.devcel.2009.12.012","title":"Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded","abstract":null,"journal":"Developmental Cell","year":2010,"id":646759,"datarank":0.931890914362728,"base_score":6.212606095751519,"endowment":6.212606095751519,"self_citation_contribution":0.931890914362728,"citation_network_contribution":0.0,"self_endowment_contribution":0.931890914362728,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":498,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":804097,"name":"Yonggang Zheng","orcid":"0000-0002-3326-4614","position":1,"is_corresponding":false},{"id":502678,"name":"Jixin Dong","orcid":"0000-0002-2757-4464","position":2,"is_corresponding":false},{"id":597189,"name":"Stephen Klusza","orcid":"0000-0003-0943-1846","position":3,"is_corresponding":false},{"id":1684740,"name":"Wu-Min Deng","orcid":null,"position":4,"is_corresponding":false},{"id":334176,"name":"Duojia Pan","orcid":"0000-0003-2890-4645","position":5,"is_corresponding":false},{"id":570323,"name":"Jianzhong Yu","orcid":"0000-0002-4883-646X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded","abstract":"The Hippo signaling pathway regulates organ size and tissue homeostasis from Drosophila to mammals. Central to this pathway is a kinase cascade wherein Hippo (Hpo), in complex with Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein, known as the YAP coactivator in mammalian cells. The FERM domain proteins Merlin (Mer) and Expanded (Ex) are upstream components that regulate Hpo activity through unknown mechanisms. Here we identify Kibra as another upstream component of the Hippo signaling pathway. We show that Kibra functions together with Mer and Ex in a protein complex localized to the apical domain of epithelial cells, and that this protein complex regulates the Hippo kinase cascade via direct binding to Hpo and Sav. These results shed light on the mechanism of Ex and Mer function and implicate Kibra as a potential tumor suppressor with relevance to neurofibromatosis.","is_dataset_classified":null,"base_score":6.212606095751519,"endowment":6.212606095751519,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20159598","pmcid":"PMC2858562","openalex_id":"https://openalex.org/W2091427349","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM072562","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM072562","title":null},{"funder_name":"NEI NIH HHS","grant_id":"R01 EY015708","title":null},{"funder_name":"NEI NIH HHS","grant_id":"EY015708","title":null},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null}],"total_grants":5,"fwci":17.9274,"citation_percentile":0.99759879,"influential_citations":0,"citation_trend":[{"year":2012,"count":46},{"year":2013,"count":40},{"year":2014,"count":41},{"year":2015,"count":35},{"year":2016,"count":32},{"year":2017,"count":26},{"year":2018,"count":31},{"year":2019,"count":41},{"year":2020,"count":32},{"year":2021,"count":18},{"year":2022,"count":29},{"year":2023,"count":23},{"year":2024,"count":21},{"year":2025,"count":16},{"year":2026,"count":7}],"oa_status":"bronze","license":"https://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"http://www.cell.com/article/S1534580710000067/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S1534580710000067/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1534580710000067?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1534580710000067?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.devcel.2009.12.012","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20159598","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2858562","host_type":"repository"}],"fields_of_study":["Hippo pathway signaling and YAP/TAZ"],"mesh_terms":["YAP-Signaling Proteins","Hippo Kinases","Animals","Cell Line","Drosophila","Female","Humans","Membrane Proteins","Nuclear Proteins","Oocytes","Phosphoproteins","Proteins","Signal Transduction","Trans-Activators","Cell Polarity","Genes, Insect","Protein Serine-Threonine Kinases","Tumor Suppressor Proteins","Neurofibromin 2","Drosophila Proteins","Animals, Genetically Modified","Multiprotein Complexes","Intracellular Signaling Peptides and Proteins","Receptors, Notch"],"keywords":["Merlin (protein)","Biology","Conjunction (astronomy)","Suppressor","Hippo signaling pathway","Cell biology","Signal transduction","Cancer research","Genetics","Cancer"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T14:49:29.327563Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}